Chinese Medical Journal. 133(1):74-85, January 5, 2020.

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Highlight: CAR-T cell treatment is safe for clinical application; however, toxicity effects should be monitored.

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Chinese Medical Journal. 132(3):294-301, February 5, 2019.

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Highlight: The international prognostic index score is a comparatively robust indicator of prognosis at 3 quartiles, and serum erythrocyte sedimentation rate is stable at the middle 2 quartiles section when adjusted for hemophagocytic lymphohistiocytosis. Quantile regression can be used to observe detailed impacts of the predictors on overall survival.

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Chinese Medical Journal. 132(15):1807-1814, August 5, 2019.

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Highlight: In comparison to patients aged 61 to 69 years, those aged ≥70 years have poorer survival. Prolonged survival is obtainable with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP)-like in elderly Chinese patients in all age groups, indicating that the R-CHOP-like regimen should be considered for this population, even for those aged 70 years or older.

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Chinese Medical Journal. 134(3):253-260, February 5, 2021.

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Highlight: This paper discussed the potential R-CHOP resistance mechanisms and proposed valuable biomarkers that can predict R - CHOP treatment resistance in the view of tumor biology (Diffuse large B cell lymphoma [DLBCL] cell origin, clonal evolution, tumor microenvironment and multi-drug resistance), potential molecular targets involving drug resistance, and epigenetic change, and also guide the treatment strategies towards relapsed/refractory DLBCL.

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Chinese Medical Journal. 132(11):1305-1313, June 5, 2019.

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Highlight: Imaging can accurately detect Extranodal natural killer/T-cell lymphoma (ENKTL) invasion of adjacent structures (AS), soft tissue, and bone. Involvement of local soft tissue or bone was significantly associated with lower 2-year overall survival (OS) rates. Involvements of the cheek or facial muscle, as well as maxilla bone, are independent predictors of lower 2-year OS rates in ENKTL patients.

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Chinese Medical Journal. 133(12):1462-1469, June 20, 2020.

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Highlight: Primary central nervous system lymphoma (PCNSL) is a rare group of extra-nodal non-Hodgkin lymphoma which is confined to the central nervous system or eyes.The prognosis of PCNSL has improved mainly due to the introduction and wide-spread use of high-dose methotrexate, which is now the backbone of all first-line treatment polychemotherapy regimens. Gene expression profiling and next-generation sequencing analyses have revealed mutations that induce activation of nuclear factor-κB, B cell antigen receptor, and Janus kinases/signal transducer and activator of transcription proteins signal pathways. In particular, lenalidomide and ibrutinib have demonstrated durable efficiency.

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