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Intestinal Microbiota

  • Creator:   Chinese Medical Journal
  • Updated:   3/23/2021
  • Contains:  9 items
The digestive tract harbours the largest and most complex microbial community of the human body, the intestinal microbiota, including about 800 different bacteria species. Bacterial colonization of human gut by environmental microbes, beginning immediately after birth, becomes more complex with increasing age, with a high degree of variability among human individuals. The gastrointestinal tract is the main site where environmental microorganisms and antigens interact with the host, through intensive cross-talks. Gut microbiota is essential for intestinal development, homeostasis and protection against pathogenic challenge.

Gut microbiota and metabolic syndrome

Wang, Peng-Xu; Deng, Xin-Ru; Zhang, Chen-Hong; More

Chinese Medical Journal. 133(7):808-816, April 5, 2020.

Highlight: This review discussed the relationship between the clinical symptoms of MetS and differences in the gut microbial community compared with healthy individuals, characterized by the proliferation of potentially harmful bacteria and the inhibition of beneficial ones.

Advances in the understanding of the intestinal micro-environment and inflammatory bowel disease

Yan, Peng-Guang; Li, Jing-Nan

Chinese Medical Journal. 133(7):834-841, April 5, 2020.

Highlight: This review summarized the recent knowledge about multi-dimensional dysbiosis, the inter-action between fungus and bacteria under inflamed mucosa, and the clinical application of probiotics and fecal microbiota transplantation as a promising therapeutic approach in IBD.

Facing a new challenge: the adverse effects of antibiotics on gut microbiota and host immunity

Zhang, Sheng; Chen, De-Chang

Chinese Medical Journal. 132(10):1135-1138, May 20, 2019.

Highlight: This editorial discussed the unfavorable effects and underlying mechanism of antibiotics on gut microbiota and host immunity, as well as possible solutions to reverse adverse effects brought about by antibiotic treatment.

Clinical utility of characterizing intestinal flora in septic kidney injury

Yuan, Jiao-Jiao; Chang, Xue-Ni; Li, Min; More

Chinese Medical Journal. 133(7):842-846, April 5, 2020.

Highlight: In sepsis, the destruction of mucosal barriers, intestinal flora disorders, intestinal ischemia/reperfusion injury, use of antibiotics, and lack of intestinal nutrients lead to an inflammatory reactions that in turn affects the metabolism and immunity of the host.

A guide to human microbiome research: study design, sample collection, and bioinformatics analysis

Qian, Xu-Bo; Chen, Tong; Xu, Yi-Ping; More

Chinese Medical Journal. 133(15):1844-1855, August 5, 2020.

Highlight: This review provided medical researchers, especially those without a bioinformatics background, with an easy-to-understand summary of the concepts and technologies used in microbiome research.