Chinese Medical Journal
Alzheimer's disease (AD) refers to a particular onset and course of cognitive and functional decline associated with age together with a particular neuropathology. Metabolic, vascular, and inflammatory changes, as well as comorbid pathologies are key components of the disease process. The clinical diagnosis may be difficult, but diagnostic methods have been introduced and proven to be accurate in supporting the clinical diagnosis. Application of these methods increases, partly due to improved awareness of cognitive symptoms and the relevance of early detection and diagnosis, in particular when more efficient disease-modifying drugs become available.