Collection Details : Chinese Medical Journal

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Update of hot topics in neuralogic diseases

  • Creator:   Chinese Medical Journal
  • Updated:   12/29/2022
  • Contains:  8 items
We summarized several high-cited articles in the field of neurology, such as relevant studies on Alzheimer's disease and other hot topics. Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a relatively rare and rapidly progressive subtype of cerebral amyloid angiopathy. The clinical symptoms are diverse and nonspecific, and the most common manifestations are subacute cognitive decline or mental disorders, headaches, seizures, etc. Asymmetric white matter hyperintensity on T2 sequence and multiple strictly lobar cerebral microbleeds are relatively characteristic imaging findings. The first article systematically summarized the pathogenesis, pathology, clinical and imaging manifestations, diagnostic criteria, treatment and prognosis of CAA-RI, and puts forward the unsolved problems and future directions for research. Numerous clinical and preclinical studies have shown that gut microbiota dysbiosis is associated with a variety of neurological diseases, e.g., Parkinson’s disease, Alzheimer’s disease, and myasthenia gravis. However, the underlying molecular mechanisms are complex and remain unclear. In the second article, authors reviewed the dysbiosis of gut microbiota and the corresponding mechanisms in common neurological diseases and discussed the potential roles that the gut microbiome may play in the diagnosis and treatment of neurological disorders.

CHCHD2 maintains mitochondrial contact site and cristae organizing system stability and protects against mitochondrial dysfunction in an experimental model of Parkinson's disease

Lu, Lin; Mao, Hengxu; Zhou, Miaomiao; More

Chinese Medical Journal. 135(13):1588-1596, July 5, 2022.

Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral β-amyloid deposition and brain atrophy

Fan, Dongyu; Li, Huiyun; Chen, Dongwan; More

Chinese Medical Journal. 135(5):591-597, March 5, 2022.