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Tumor-induced osteomalacia with IgG4-related lymph node disease

Zhang, Ye1; Xu, Chang2; Yang, Yan1

Section Editor(s): Guo, Li-Shao

doi: 10.1097/CM9.0000000000000188

1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

2Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Correspondence to: Dr. Yan Yang, Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Avenue, Qiaokou District, Wuhan, Hubei 430030, China E-Mail:

How to cite this article: Zhang Y, Xu C, Yang Y. Tumor-induced osteomalacia with IgG4-related lymph node disease. Chin Med J 2019;00:00–00. doi: 10.1097/CM9.0000000000000188

Received 5 December, 2018

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

To the Editor: A 60-year-old man presented with progressively worsened limb weakness of 4 years duration, which had rendered him wheelchair-bound since May 2018. The patient also had muscle and joint pain and numbness. He had a history of type 2 diabetes, hypertension, and gout, no family history of bone disease. He took diabetic peripheral neuropathy treatment but the symptoms kept progressing. On admission, the patient was well developed and in normal body shape. Physical examination was unremarkable except for all-sided weakness. Laboratory evaluation showed hypophosphatemia with notable elevated urinary phosphorus loss. Other laboratory abnormalities were elevated alkaline phosphatase levels, mild insufficient vitamin D status, and mild elevated parathyroid hormone. After bone scintigraphy failed to localize an osseous tumor, whole-body positron emission tomography (PET)/computed tomography (CT) using 18F-fluorodeoxyglucose (18F-FDG) and the radiolabeled somatostatin analog 68Ga-DOTATATE were performed to make clear diagnosis of oncogenic hypophosphatemic osteomalacia. Both of the examinations revealed a suspicious mass in subcutaneous tissue around the umbilicus and enlarged right axillary lymph nodes [Figure 1A and 1B].

Figure 1

Figure 1

The patient was subjected to surgery for resection of the subcutaneous mass and enlarged right axillary lymph nodes after obtaining written informed consent. The subcutaneous mass was red, round-shaped without necrosis. It displayed spindle-shaped cells with oval nuclear and eosinophilic cytoplasm, and characteristic scattered cloud-like calcium deposits under histologic examination. No atypical cells, abnormal mitotic activity, or necrosis were observed [Figure 1C]. On the basis of its morphologic and immunohistochemical features, the tumor was diagnosed as a phosphaturic mesenchymal tumor. Interestingly, histologic examination of lymph nodes revealed immunoglobulin G (IgG) 4-positive plasma cells >100 cells per high-power field, and the IgG4-positive rate was up to 70% of IgG-positive plasma cells in intra-follicular zones [Figure 1D]. Supplemental laboratory testing demonstrated elevated IgG4/IgG ratio, thus an IgG4 lymph node disease could be diagnosed.

The patient was released from the hospital after a rapid recovery of serum phosphorous [Figure 1E] and urinary phosphorus loss. He reported normal serum phosphorous and significantly improved symptoms during our one and a half months follow-up.

Tumor-induced osteomalacia (TIO) is a rarely seen tumor-related disease with characteristics of hypophosphatemia and abnormal urinary phosphate wasting. The increased level of fibroblast growth factor 23 (FGF23), a circulating phosphaturic hormone produced by tumors leads to decreased renal phosphate reabsorption through reduction of the sodium-phosphate co-transporter expression in the proximal renal tubule. Clinically, patients suffering from TIO may develop weakness, fatigue, bone, muscle pain, and fractures.

Tumors resulting in TIO are often too small to localize by conventional radiologic methods. In the case that anatomical imaging (CT or magnetic resonance imaging) fail to detect the tumors, scintigraphy with a radiolabeled somatostatin analog (111indium octreotide scintigraphy or 68Ga-DOTATATE PET/CT) with or without 18F-FDG PET/CT is recommended. Selective venous sampling with FGF23 should be taken into consideration when other tests come to nothing.

IgG4-related diseases (IgG4-RD) is a fibro-inflammatory condition involving multiple organs characterized by storiform fibrosis, increased serum IgG4 level, and inflammatory infiltrate with IgG4-rich plasma cells. It was reported that patients with IgG4-RD had higher risks of solid and hematologic malignancies than the general population.[1,2] Furthermore, history of malignancy may be related to subsequent IgG4-RD development.[3] However, the connection between IgG4-RD and malignancy still remains unclear. Some studies claimed no connection between IgG4-RD and malignancy. A Japanese prospective study found that the incidence of total malignancies in IgG4-RD patients was similar to that in the general population.[4] Pathogenesis of IgG4-RD and TIO are totally different as immunity-related and FGF-23 related. We speculate that there is no association between TIO and IgG4-RD in this patient.

Here, we presented a 60-year-old man who had suffered from severe clinical manifestations of TIO due to a mesenchymal tumor in the umbilicus and was discovered an IgG4 lymph node disease accidentally. In this case, the tumor was identified by 68Ga-DOTATATE PET/CT and surgical removal of the tumor resulted in significant relief of symptoms and hypophosphoremia. When meeting with unexplained bone pain and fatigue, TIO should always be taken into consideration and scintigraphy with a radiolabeled somatostatin analog should be applied early when routine examination failed to detect tumors.

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Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given his consent for his images and other clinical information to be reported in the article. The patient understands that his name and initial will not be published and due efforts will be made to conceal the identity of the patient, although anonymity cannot be guaranteed.

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The authors thank Yun-Feng Han for whole-body positron emission tomography scan with radiolabeled somatostatin analog of the patient.

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This work was supported by a grant from the National Natural Science Foundation of China (No. 81670754).

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Conflicts of interest


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2. Asano J, Watanabe T, Oguchi T, Kanai K, Maruyama M, Ito T, et al. Association between immunoglobulin G4-related disease and malignancy within 12 years after diagnosis: an analysis after longterm followup. J Rheumatol 2015; 42:2135–2142. doi: 10.3899/jrheum.150436.
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