The younger patient was 28 years old, admitted to our hospital with a history of jaundice and steatorrhea. Biochemical test showed that he got diabetes mellitus. Diagnostic imaging demonstrated a pancreatic pseudocyst at the head of pancreas. Fine-needle aspiration pathology showed developed adenocarcinoma. After a comprehensive assessment, the patient was considered to have chemotherapy. Other laboratory test results: antinuclear antibody profile R0–52 (+), liver autoantibodies (-), keratin antibody (-), anti-neutrophil cytoplasmic antibodies (ANCA) (-). Serum hyaluronic acid and collagen IV of this patient was significantly higher than other patients.
In the last years, many studies show that trypsin plays an important role in physiological functions and physiological processes such as digestion, coagulation function, embryonic development, et al.11,12 Once the trypsinogen was activated, lots of proenzymes would turn into isozyme which leads to cell response. That is to say, trypsinogen plays an important role in maintaining environmental balance, if its function or quantity is destroyed; the immune system may lose its balance and can not detect the mutational cell.
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