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Etiologies and Outcomes of Acute Respiratory Distress Syndrome With No Identified Common Risk Factor

Gibelin, Aude MD*,†,‡; Parrot, Antoine MD*,§; Fartoukh, Muriel MD, PhD*,†,‡; de Prost, Nicolas MD, PhD‡,∥

doi: 10.1097/CPM.0000000000000314
Critical Care/Respiratory Care

Almost 10% of patients with acute respiratory distress syndrome (ARDS) have no identified ARDS risk factor at ARDS diagnosis. A prompt identification of the cause of ARDS is required to initiate a targeted treatment. The purpose of this review is to delineate the main rare causes of ARDS and to provide clinicians with a pragmatic diagnostic workup. Recent epidemiological data have proposed the identification of a subgroup of ARDS patients lacking exposure to common risk factors. These can be categorized as having immune-mediated, drug-induced, malignant, and idiopathic diseases. A standardized diagnostic workup including chest imaging, the objective assessment of left-heart–filling pressures, bronchoalveolar lavage fluid microbiological investigations, and cytologic analysis, immunologic tests, and search for pneumotoxic drugs may allow for identifying the cause of ARDS in most cases. Open-lung biopsy should be considered in other cases.

*Medical and Surgical Intensive Care Unit

§Pulmonology department, Assistance Publique-Hôpitaux de Paris, Hôpital Tenon, Pôle Thorax Voies aériennes, Groupe hospitalier des Hôpitaux Universitaires de l’Est Parisien

Faculté de Médecine Sorbonne Université, Paris

Groupe de Recherche Clinique CARMAS, Faculté de Médecine de Créteil, Université Paris Est Créteil

Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, DHU A-TVB, Créteil, France

Disclosure: The authors declare that they have no conflicts of interest.

Address correspondence to: Nicolas de Prost, MD, PhD, Medical and Surgical Intensive Care Unit, Hôpital Henri Mondor, 51, Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil Cedex, France. E-mail:

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