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The Clinical and Research Utility of Bronchoscopy in Cystic Fibrosis

Izquierdo, Manuel DO*; Marion, Chad DO, PhD; Tumin, Dmitry PhD; Bowling, Mark R. MD§; Ortega, Victor E. MD, PhD†,∥

Clinical Pulmonary Medicine: May 2019 - Volume 26 - Issue 3 - p 76–81
doi: 10.1097/CPM.0000000000000305
Topics in Pulmonary Medicine

Bronchoscopy is used in the management of cystic fibrosis (CF) for multiple reasons, of which sampling respiratory secretions has been the most frequent. The evidence behind the role of bronchoscopy for routine sampling of respiratory secretions to determine clinical management is lacking, although there remain well-accepted indications for bronchoscopy in research and follow-up of advanced therapies in the CF population. We review the clinical and research utility of bronchoscopy in patients with CF and outline promising research uses of this tool that can contribute to recent advances in understanding and treating CF.

*Department of Internal Medicine-Pediatrics Program

Department of Pediatrics

§Section on Pulmonary, Critical Care, and Sleep Medicine, Brody School of Medicine, East Carolina University, Greenville

Department of Internal Medicine, Section on Pulmonary and Critical Care, Wake Forest Baptist Medical Center

Department of Internal Medicine, Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, NC

Disclosure: The authors declare that they have no conflicts of interest.

Address correspondence to: Manuel Izquierdo, DO, 517 Moye Boulevard, 2nd Floor, East Carolina University, Greenville, NC 27834-4354. E-mail:

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