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Subtle But Clinically Significant

A Review of Antibody Deficiencies in Adults

Harada, Kaoru MD*; Price, Christina MD†,‡

Clinical Pulmonary Medicine: May 2019 - Volume 26 - Issue 3 - p 71–75
doi: 10.1097/CPM.0000000000000304
Respiratory Infections

Primary immunodeficiency diseases are becoming more frequently diagnosed in the adult population. Although infections are the most common symptoms, patients can also present with sequelae of autoimmune and noninfectious pulmonary diseases, such as interstitial lung disease and granulomatous disease. Pulmonologists are likely to encounter patients with various and, at times, subtle symptoms suggestive of immunodeficiency. In this review article, we discuss the presentation, evaluation, and management of 4 antibody deficiencies: common variable immunodeficiency, selective immunoglobulin A deficiency, specific antibody deficiency, and immunoglobulin G subclass deficiency.

*Department of Internal Medicine, Yale School of Medicine

Yale School of Medicine, Allergy and Clinical Immunology, New Haven

Veterans Affairs Medical Center, Allergy and Immunology, West Haven, CT

Disclosure: C.P. is on the advisory board for CSL Behring. K.H. declares no conflicts of interest.

Address correspondence to: Kaoru Harada, MD, 333 Cedar Street, P.O. Box 208013, New Haven, CT 06520-8013. E-mail:

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