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Can Quadrupling Inhaled Glucocorticoid Dose During Early Asthma Exacerbation Reduce the Need For Systemic Steroids or Hospital Admission?

Chung, Samuel MD; Zappetti, Dana MD

doi: 10.1097/CPM.0000000000000310
Pulmonary Trends

Synopsis: In this unblinded, multicenter, randomized control trial, patients with mild asthma who quadrupled the dose of their inhaled glucocorticoids upon initial signs of asthma control deterioration experienced fewer severe asthma exacerbations than patients who did not quadruple their inhaled glucocorticoid dose.

Source: McKeever T, Mortimer K, Wilson A, et al. Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations. N Engl J Med. 2018;378:902–910.

Disclosure: The authors declare that they have no conflicts of interest.

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