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Management of Pulmonary Vasculitis

A Concise Review

Tiwari, Anupama, MD*; Bowling, Mark, MD

doi: 10.1097/CPM.0000000000000299
Interstitial, Inflammatory & Occupational Lung Disease
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The pulmonary vasculitides are an uncommon group of disorders that are characterized by inflammation and necrosis of the blood vessel wall, usually involving the small and medium-sized blood vessels in the lung. Management has traditionally involved the use of immunosuppressive agents and newer adjunctive therapies such as plasmapheresis. Recent trials over the last decade have highlighted the successful use of these agents in treating this life-threatening illness; however, much remains unknown in terms of exact dosing of these agents and duration of treatment. Adverse events from these therapies remain a serious concern requiring close monitoring and a multidisciplinary approach. Other advances in this field include exploration of newer drugs, some of which are currently being used in randomized trials. This review is an update on the advances made in the management of pulmonary vasculitis over recent years, along with a suggested uniform approach to management based on disease severity classification.

*Division of Pulmonary/Critical Care & Sleep, Albany Medical College, New York, NY

Division of Pulmonary/Critical Care & Sleep Medicine, Brody School of Medicine, East Carolina University, Greenville, NC

Disclosure: The authors declare that they have no conflicts of interest.

Address correspondence to: Anupama Tiwari, MD, Division of Pulmonary/Critical Care & Sleep Medicine, Albany Medical College, 16 New Scotland Avenue MC-91, Albany, NY 12208. E-mail: anupulm@gmail.com.

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