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Does Dose Matter in Intravenous Thrombolysis for Acute Pulmonary Embolism?

Sonnick, Mark A., MD; Zappetti, Dana, MD

Clinical Pulmonary Medicine: January 2019 - Volume 26 - Issue 1 - p 36
doi: 10.1097/CPM.0000000000000292
Pulmonary Trends

Synopsis: In a retrospective analysis of intensive care unit patients using voluntarily reported national data, half-dose intravenous tissue plasminogen activator (tPA) for acute pulmonary embolism increased the need for escalation of care when compared with full-dose intravenous tPA. There was a lower risk of bleeding for half-dose tPA.

Source: Kiser TH, Burnham EL, Clark B, et al. Half-dose versus full-dose alteplase for treatment of pulmonary embolism. Crit Care Med. 2018;46(10).

Disclosure: The authors declare that they have no conflicts of interest.

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