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The Role of Rhinovirus in the Pathogenesis and Acute Exacerbation of Asthma

Klaiber, Nicholas, MD

doi: 10.1097/CPM.0000000000000244
Respiratory Infections/Obstructive Airways Disease

Rhinovirus (RV) is the most common pathogen detected in the nasopharynx of individuals suffering from asthma exacerbation. Experimental data indicate that in addition to its prominent role in acute asthma exacerbation, RV may also serve as an environmental agent driving airway remodeling and bronchial hyperresponsiveness. Understanding the host-pathogen interplay, which results in both acute asthma exacerbation and the instigation of burgeoning disease, may highlight potential avenues for more effective therapeutic interventions. This review summarizes recent data as regards the relationship between RV infection, asthma exacerbation, and asthma pathogenesis.

Department of Allergy and Immunology, VCU Medical Center, Richmond, VA

Disclosures: The authors declare that they have no conflicts of interest.

Address correspondence to: Nicholas Klaiber, MD, VCU Medical Center, 5th floor 5-332, 1000 E Broad Street, Richmond, VA 23298. E-mail:

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