Interstitial, Inflammatory and Occupational Lung DiseaseInterstitial Pneumonia With Autoimmune Features: Overview of Proposed Criteria and Recent Cohort CharacterizationLee, Cathryn T. MD*; Oldham, Justin M. MD, MS† Author Information *Department of Medicine, Section of Pulmonary and Critical Care, University of Chicago, Chicago, IL †Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of California, Davis, Sacramento, CA Disclosure: J.M.O. has received speaking fees and sat on advisory boards for Genentech and Boehringer Ingelheim. J.M.O. has received a grant from the National Center for Advancing Translational Sciences, award number KL2 TR001859. The remaining author declares that he has no conflicts of interest. Address correspondence to: Justin M. Oldham, MD, MS, Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of California, Davis, Sacramento, CA 95817. E-mail: [email protected]. Clinical Pulmonary Medicine: September 2017 - Volume 24 - Issue 5 - p 191-196 doi: 10.1097/CPM.0000000000000227 Buy Metrics Abstract The accurate diagnosis of interstitial lung disease is essential for optimal prognostication and management. Although connective tissue disease is among the most common causes of interstitial lung disease, some patients have features suggestive of autoimmunity without meeting criteria for a specific connective tissue disease. To help define and study this disease entity more uniformly, a 2015 research statement proposed consensus-based criteria and coined the term “interstitial pneumonia with autoimmune features” (IPAF). In this review, we summarize and compare previously proposed criteria to characterize these patients, provide an overview of the IPAF criteria, and highlight recent investigations aimed at characterizing IPAF cohorts. Thereafter, we call attention to questions that have arisen with the application of the IPAF criteria and discuss future areas of study. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.