Interstitial lung disease is a heterogenous group of disorders characterized by varying patterns of inflammation and fibrosis. Its diagnosis requires a multidisciplinary approach including clinical and imaging correlation, but atypical presentations and imaging warrant tissue biopsy. Transbronchial forceps biopsy has a low yield and is not recommended for diagnosis. Although considered as the gold standard, surgical lung biopsy is associated with significant morbidity and mortality. Transbronchial cryobiopsy is a relatively newer technique, but only limited data are available to establish its utility in diagnosing interstitial lung disease and evaluating the associated risks to this procedure.
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Department of Internal Medicine, Division of Pulmonary, Critical Care, Allergy, and Immunologic Disease, Wake Forest School of Medicine, Winston Salem, NC
Disclosure: The authors declare that they have no conflicts of interest.
Address correspondence to: Deepankar Sharma, MD, Department of Internal Medicine, Division of Pulmonary, Critical Care, Allergy, and Immunologic Disease, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157. E-mail: firstname.lastname@example.org.