Images in Pulmonary MedicineMultifocal Recurrent Lung Opacities in a Renal Failure PatientPanse, Prasad M. MD*; Jensen, Eric A. MD*; Cummings, Kristopher W. MD*; Jokerst, Clinton E. MD*; Viggiano, Robert W. MD†; Smith, Maxwell L. MD‡; Gotway, Michael B. MD*Author Information *Department of Radiology, Mayo Clinic, Phoenix Departments of †Medicine, Division of Pulmonary Medicine ‡Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ Disclosure: The authors declare that they have no conflicts of interest. Address correspondence to: Michael B. Gotway, MD, Department of Radiology, Mayo Clinic, 5777 East Mayo Blvd, Phoenix, AZ 85054. E-mail: email@example.com. Clinical Pulmonary Medicine: September 2016 - Volume 23 - Issue 5 - p 231-236 doi: 10.1097/CPM.0000000000000175 Buy Metrics Abstract Pulmonary vasculitides include a broad variety of disorders having in common inflammation and destruction of the blood vessels within the lung. Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is an antineutrophil cytoplasmic antibody (ANCA)-associated small-vessel vasculitis that affects a number of organ systems, and is the most common of the ANCA-associated vasculitides. GPA affects a broad age range, most commonly presenting in middle-aged adults. The classic triad of GPA, the combination of upper-airway disease (sinusitis, otitis media, ulcerations, tracheobronchial stenoses), lower-respiratory tract disease, and glomerulonephritis, is not always evident at presentation. Imaging manifestations of GPA commonly include multiple, bilateral nodules or masses that often show cavitation or necrosis. Less commonly, diffuse lung opacity resulting from alveolar hemorrhage, or tracheobronchial stenoses, may be seen. The diagnosis of systemic GPA can often be suggested when c-ANCA/anti-PR-3 antibodies are detected in the proper clinical context, but not infrequently, the diagnosis rests on recognition of a combination of characteristic clinical, laboratory, and imaging findings in combination with histopathologic material from a biopsy. The mainstay of treatment of GPA is corticosteroid therapy in combination with other immunosuppressive agents. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.