Images in Pulmonary MedicineSarcomatoid Lung Carcinoma Case and Clinicopathologic ReviewSaccone, Peter J. DO*; Morley, Thomas DO, FACOI*; Roy, Darshan MD†; Liu, Jun MD, PhD†Author Information *Rowan University School of Osteopathic Medicine, Stratford, NJ †Kennedy Health System, Cherry Hill, NJ Disclosure: The authors declare that they have no conflicts of interest. Address correspondence to: Peter J. Saccone, DO, 20 Red Gravel Circle, Sicklerville, NJ 08081. E-mail: [email protected]. Clinical Pulmonary Medicine: March 2015 - Volume 22 - Issue 2 - p 100-104 doi: 10.1097/CPM.0000000000000082 Buy Metrics Abstract Lung cancer remains the leading cause of cancer deaths in both men and women in the United States. Lung cancers are broadly divided into non–small cell lung carcinomas and small cell carcinomas for treatment purposes; non–small cell carcinoma is by far the most common type of bronchogenic malignancy. Rare primary pulmonary malignancies include adenosquamous carcinoma, carcinoid tumors, minor salivary gland tumors, and poorly differentiated lung malignancies with sarcomatoid differentiation; the latter are referred to under the umbrella term “sarcomatoid carcinomas.” Sarcomatoid lung carcinomas account for 0.1% to 0.3% of all lung cancer diagnoses. These malignancies often present at imaging as nonspecific peripherally located masses that may be associated with chest wall invasion. Sarcomatoid carcinomas are aggressive cancers associated with a poor prognosis. Although they may present with clinical features resembling other non–small cell lung malignancies, the pathologic features, response to treatment, and prognosis of sarcomatoid carcinomas often differ from other non–small cell lung malignancies. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.