Obstructive Airways DiseaseDiagnosis and Management of Concomitant Cystic Fibrosis in Patients With Chronic Obstructive Pulmonary DiseaseKirkby, Stephen MD*,†; Teferra, Rahel MD*; Patel, Alpa MD†; Cormet-Boyaka, Estelle PhD*; Hayes, Don Jr MD, MS*,†Author Information *Department of Pulmonary, Allergy, Critical Care and Sleep Medicine †Section of Pediatric Pulmonary Medicine, Nationwide Children’s Hospital, The Ohio State University, Columbus, OH The authors declare that they have nothing to disclose. Address correspondence to: Stephen Kirkby, MD, Section of Pediatric Pulmonary Medicine, Ohio State University Medical Center, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205. E-mail: email@example.com. Clinical Pulmonary Medicine: May 2013 - Volume 20 - Issue 3 - p 113-116 doi: 10.1097/CPM.0b013e31828fc8b1 Buy Metrics Abstract Chronic obstructive pulmonary disease (COPD) and cystic fibrosis share key clinical features such as chronic airway inflammation and obstructive airflow limitation, and both diseases may lead to chronic respiratory failure and death. Cigarette smoke, well-known to be the major cause of COPD, contributes to suppression of the expression and function of cystic fibrosis transmembrane conductance regulator protein. Likewise, there is evidence that cystic fibrosis transmembrane conductance regulator dysfunction may contribute to key molecular pathways involved in the pathogenesis of COPD. We present 3 adult patients with extensive cigarette smoking histories and COPD who were subsequently diagnosed with cystic fibrosis and describe the management strategy implemented. © 2013 Lippincott Williams & Wilkins, Inc.