Navdeep K. Brar, MD
Synopsis: Dexmedetomidine showed similar efficacy to propofol and midazolam in maintaining mild-moderate levels of sedation. Patients treated with midazolam required a longer duration of mechanical ventilation. All 3 agents performed similarly otherwise.
Source: Jakob SM, Ruokonen E, Grounds RM, et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA. 2012;307:1151–1160.