Respiratory InfectionsRapid Detection of Microorganism Resistance in Patients With Ventilator-Associated PneumoniaMuñoz, Patricia MD, PhD; Cercenado, Emilia PharmD; Giannella, Maddalena MD; Bouza, Emilio MD, PhDAuthor Information From the Clinical Microbiology and Infectious Diseases Division, Hospital General Universitario Gregorio Marañón-CIBER de Enfermedades Respiratorias (CIBERES) and GESITRA-REIPI, Universidad Complutense, Madrid, Spain. Address correspondence to: Patricia Muñoz, MD, PhD, Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Dr. Esquerdo 46, Madrid, Spain. E-mail: [email protected]. Clinical Pulmonary Medicine: November 2009 - Volume 16 - Issue 6 - p 302-308 doi: 10.1097/CPM.0b013e3181be0198 Buy Metrics AbstractIn Brief Early optimal antimicrobial therapy is an essential part of the successful management of ventilator-associated pneumonia because inadequate initial therapy is consistently associated with increased mortality. Standard bacterial isolation, followed by identification and antimicrobial susceptibility testing usually takes no fewer than 2 to 3 days in the microbiology laboratory. An early report based on the results obtained directly by plating LRT secretions with 6 E-test strips is associated with better antibiotic use, less antimicrobial misuse, and a decrease in antimicrobial-related adverse events. New molecular methods are being developed. Rapid, even imprecise information from the microbiology laboratory may be of greater value than delayed and more precise information in patients with ventilator-associated pneumonia. An early report based on the results obtained directly by plating LRT secretions with 6 E-test strips is associated with better antibiotic use, less antimicrobial misuse and a decrease in antimicrobial-related adverse events. New chromogenic and molecular methods may also contribute to reduce antimicrobial misuse in patients with ventilator-associated pneumonia. © 2009 Lippincott Williams & Wilkins, Inc.