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Hypercoagulability in Obstructive Sleep Apnea

Guardiola, Juan J. M.D.; Fletcher, Eugene C. M.D.; Alhariri, H. M.D.; Hasan, Nuzhat M.D.

Clinical Pulmonary Medicine: July 2001 - Volume 8 - Issue 4 - p 238-241
Topics In Pulmonary Medicine
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In patients with obstructive sleep apnea, blood hypercoagulability may contribute to an increased risk of cardiovascular events. The main causes of hypercoagulability related to obstructive sleep apnea are hyperfibrinogenemia, decreased fibrinolytic activity, platelet function abnormalities, erythrocytosis, and vascular endothelial dysfunction. This hypercoagulable state may be related to recurrent episodic hypoxia during sleep apnea.

From the Division of Respiratory, Critical Care, and Environmental Medicine, University of Louisville School of Medicine, Louisville, KY.

Address correspondence to: Juan J. Guardiola, M.D., Division of Respiratory, Critical Care, and Environmental Medicine, University of Louisville School of Medicine, 530 S Jackson St, ACB-3, Louisville, KY 40292.

© 2001 Lippincott Williams & Wilkins, Inc.