Infectious complications and survival were compared for invasive versus noninvasive ventilation for patients with acute hypercapnic exacerbations of chronic obstructive pulmonary disease (COPD) with respiratory failure and acute cardiogenic pulmonary edema (CPE) in a case-control study. The study showed a reduced incidence of infections and a lower mortality rate for the patients treated with noninvasive ventilation.
Girou E et al. Association of noninvasive ventilation with nosocomial infections and survival in critically ill patients. JAMA. 2000;284:2361–2367.