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Letter to the Editor: Increased Risk of Revision, Reoperation, and Implant Constraint in TKA After Multiligament Knee Surgery

Ayubi, Erfan PhD1; Safiri, Saeid PhD2,3,a

Clinical Orthopaedics and Related Research®: October 2017 - Volume 475 - Issue 10 - p 2610–2611
doi: 10.1007/s11999-017-5465-8
Letter to the Editor
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1Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, North Moallem Street, Maragheh, Iran

3Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

ae-mail; saeidsafiri@gmail.com

Received May 28, 2017/Accepted July 31, 2017; previously published online August 7, 2017

(RE: Pancio SI, Sousa PL, Krych AJ, Abdel MP, Levy BA, Dahm DL, Stuart MJ. Increased Risk of Revision, Reoperation, and Implant Constraint in TKA After Multiligament Knee Surgery. Clin Orthop Relat Res. 2017;475:1618-1626).

The authors certify that neither they, nor any members of their immediate families, have any commercial associations (such as consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article.

All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request.

The opinions expressed are those of the writers, and do not reflect the opinion or policy of CORR® or The Association of Bone and Joint Surgeons®.

To the Editor,

In their study, Pancio and colleagues [6], retrospectively evaluated implant survival, complication rate, and long-term outcomes of knee arthroplasty in patients with a prior history of multiligament surgery. The authors found that patients with a prior history of multiligament surgery more frequently received varus-valgus constraint compared with patients undergoing primary knee arthroplasty for osteoarthritis. These results also showed large effect size estimates, but those estimates had wide confidence intervals (CI).

Previous studies [4, 5] showed that wide CIs around large effect-size estimates may indicate sparse-data bias, an estimate inflation that occurs “when the data lack adequate case numbers for some combination of risk factor and outcome levels” [5]. When this occurs, “the resulting estimates of the regression coefficients can have bias away from the null (downward when the estimate is below 1, upward when it is above 1)” [5]. Additionally, sparse-data bias can cause imprecise CIs [5].

Sparse-data bias is generally found if the sample size is relatively small or when there are different sample sizes in the exposure and intervention groups [1-3, 5, 7]. To address and adjust this bias, researchers developed the conventional method, which adds a half count to every strata in the table. Greenland and colleagues [5] introduced an alternative to the conventional method called penalization via data augmentation, an efficient method “in which external (or prior) information is used to improve accuracy over repeated studies” [5]. Penalization via data augmentation better addresses bias compared to conventional methods by removing or correcting the bias [5].

In Table 4 of the study by Pancio and colleagues, the sample size in the “increased-constraint” group at primary TKA is quite small (n = 9), potentially rendering this dataset to sparse-data bias. We recommend using the penalization method to adjust the sparse-data bias. The results of the penalized regression model showed a decreased effect-size estimate (smaller odds ratios), with narrower and, we believe, more-precise CIs (Table 1).

Table 1

Table 1

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References

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5. Greenland S, Mansournia MA, Altman DG. Sparse data bias: A problem hiding in plain sight. BMJ. 2016;352:i1981 10.1136/bmj.i1981.
6. Pancio SI, Sousa PL, Krych AJ, Abdel MP, Levy BA, Dahm DL, Stuart MJ. Increased risk of revision, reoperation, and implant constraint in TKA after multiligament knee surgery. Clin Orthop Relat Res. 2017;475:1618-1626 10.1007/s11999-017-5230-z.
7. Safiri S, Ayubi E. Dual photon microscopy based quantitation of fibrosis-related parameters (q-FP) to model disease progression in steatohepatitis: Methodological issues. Hepatology. [Published online ahead of print May 16, 2017]. DOI: 10.1002/hep.29261.
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