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Symposium: Improving Care for Patients With ACL Injuries: A Team Approach

Does the FIFA 11+ Injury Prevention Program Reduce the Incidence of ACL Injury in Male Soccer Players?

Silvers-Granelli, Holly J. MPT1,5,a; Bizzini, Mario PhD, MSC, PT2; Arundale, Amelia DPT1; Mandelbaum, Bert R. MD3; Snyder-Mackler, Lynn PT, ScD4

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Clinical Orthopaedics and Related Research: October 2017 - Volume 475 - Issue 10 - p 2447-2455
doi: 10.1007/s11999-017-5342-5
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Soccer-related injuries are a relatively common occurrence across sex, age, and level of competition. The high prevalence of soccer-related injury has been well documented [5, 6, 13, 19, 20, 22, 23, 26, 31, 35]. Injuries incurred during soccer most commonly involve the lower extremity and most commonly occur in a game situation [9, 10, 18, 21]. The National Collegiate Athletic Association (NCAA) has reported that the game-related injury rate in men's and women's soccer games ranked third and fourth for all NCAA sports, respectively [1, 2]. Anterior cruciate ligament (ACL) injuries continue to consistently negatively impact recreational, competitive, and professional athletes globally. There are approximately 200,000 ACL injuries that occur in the United States annually making it the most commonly injured ligament in the knee [3, 28]. The NCAA's Injury Surveillance System (ISS and DATALYS) reported that the overall ACL injury rates were 1.45 per 10,000 athletic exposures for female athletes and 0.60 per 10,000 athletic exposures for male athletes [48]. Gilchrist et al. [25] noted that 31% of Division I soccer athletes polled had a history of knee injury and 14% had a history of ACL injury. The documented increase in incidence and the increased risk associated with prior knee injury initiate an obvious concern for the health and integrity of the articular cartilage of the knee in this young athletic cohort longitudinally [12, 17, 36, 38, 52].

For the last three decades, there has been a variety of effective ACL injury prevention programs developed, namely for high-risk sports [11, 14, 25, 32, 39-41, 46, 47]. Many of these programs have focused specifically on female athletes [25, 33, 39, 40, 47, 50] and have included a variety of strengthening, plyometric, and agility-based drills that addressed the major deficits most commonly associated with ACL injury [24, 27, 29]. Several programs have been designed as dynamic warm-up programs to increase program utilization and compliance and to capitalize on the biomechanical advantages associated with improved joint position sense [39, 45, 47]. Despite the development and the evolution of the aforementioned programs, there is a continued and implicit need to address soccer-related injury in totality. The FIFA 11+ injury prevention program was designed to address all soccer-related injuries not only specific to the knee or to the ACL [47]. It is a dynamic on-the-field warm-up that is time-efficient and requires no additional equipment. The efficacy of the program has been documented and decreases in overall injury rate have been shown in both male and female soccer players [30, 44, 46, 47]. However, prior studies did not specifically analyze the ability of the FIFA 11+ prevention program to reduce the number of ACL injuries in male soccer players.

The purpose of this study was to examine if the FIFA 11+ injury prevention program can (1) reduce the overall number of ACL injuries in men who play competitive college soccer and whether any potential reduction in rate of ACL injuries differed based on (2) game versus practice setting; (3) player position; (4) level of play (Division I or II); or (5) field type.

Patients and Methods

As previously reported in an earlier publication, a prospective cluster randomized controlled trial was conducted in Division I and Division II NCAA men's soccer teams in the Fall 2012 season [46]. Every NCAA member institution with a men's Division I or Division II soccer program (N = 396) was contacted through a formal letter, email, and a direct phone call. The correspondence included a hyperlink for a video that featured former and current prominent US soccer players and a coach who discussed the nature and importance of prevention in the sport of soccer ( and Of the 396 eligible teams, 299 met the inclusion criteria. Sixty-five institutions consented to participate with the male participants from each institution ranging in age from 18 to 25 years. The additional institutions opted out of the study noting time restrictions, no current issues with injuries in their team, not enough coaching staff to implement the program, not wanting to implement the program in the competitive fall season, or lack of interest. Human ethics internal review board approval was obtained through the Quorum institutional review board (Seattle, WA, USA).

The inclusion criteria stipulated that each subject was a male college soccer player between the ages of 18 and 25 years in good academic standing and was medically cleared to participate in the 2012 season. The teams confirmed that they had not participated in an injury prevention program in the past 4 academic years to avoid subject contamination. Before simple computer-generated team randomization, individual player informed consent was obtained and a documentation of coaching understanding was signed by each institution to ensure robust comprehension of the expectations of study participation.

On computer-generated randomization of the enrolled institutions, the intervention group received an instructional FIFA 11+ DVD, prevention manual, and explanatory placards describing the FIFA 11+ intervention ( The FIFA 11+ is a 15- to 20-minute on-the-field dynamic warm-up program used before games and training performed two to three times a week throughout the entire season. It includes strength, agility, proprioceptive, and plyometric exercises and was designed to reduce injuries most commonly identified in soccer players.

A secure Internet-based injury surveillance system was utilized (HealtheAthlete; Cerner Corporation, Overland Park, KS, USA) by every enrolled institution (control group and intervention group). Every athletic exposure, injury incurred (including ACL injury), mechanism of injury, and date of return to play were entered weekly by the team's certified athletic trainer. The environmental conditions of the ACL injury were also considered with respect to field type: grass versus artificial turf. Sixty-five institutions were randomized using a simple computer-generated randomization and 61 completed the study during the Fall 2012 season (August to December): 34 control institutions (N = 850 athletes; 17 Division I teams [425 players] and 17 Division II teams [425 players]) and 27 intervention institutions (N = 675 athletes; 16 Division I teams [400 players] and 11 Division II teams [275 players]) (Fig. 1). Demographic information including age, position played, and leg dominance was also collected. During the course of the season, the research staff monitored the data entry for each institution. In the event that no logon to the injury surveillance system was detected and no data were uploaded into the system for 14 days, a computer-generated email was dispersed and a research staff member followed up immediately. On the completion of the season, the data entry was confirmed by each certified athletic trainer and the accuracy and completeness with their individual institution's internal data collection system were established. As a result of the loss of four intervention teams to followup, a per-protocol analysis of the data was completed.

Fig. 1:
Description of the NCAA team randomization and study flow is presented.

Statistical Analysis

All statistical analyses were conducted utilizing IBM SPSS Statistics Editor for MAC Version 24 (IBM Corporation, Armonk, NY, USA). Descriptive and inferential tests were used to compare the control group and intervention group, including frequency counts, t-tests, chi-square tests, factorial analysis of variance, and logistic regression tests (Biostatistics Core Facility University of Delaware, Newark, DE, USA). Injury rates were calculated based on athletic exposures and are expressed as a rate per 1000 athletic exposures.


There were 1305 overall team exposures to the FIFA 11+ in the intervention group (405 games and 900 training sessions) over the course of the season with an average of 2.19 FIFA 11+ utilizations over the course of the season per week. The control group consisted of 850 athletes (34 teams [56%]) who had 44,212 athletic exposures (games: 13,624 and practices: 30,588). The intervention group consisted of 675 athletes (27 teams; 44%) who had 35,226 athletic exposures (games: 10,935 and practices: 24,291) (Fig. 1) [46]. There was no difference between the ages of the athletes at the time of ACL injury (control group: 20.68 ± 1.46 years versus intervention group: 20.40 ± 1.66 years, range, 20.24-21.81, p = 0.914) (Table 1). The risk of ACL injury was lower in the teams that used FIFA 11+ than in those that did not (1.1% [three of 19] versus 2.4% [16 of 19]; relative risk [RR], 0.24; 95% confidence interval [CI], 0.07-0.81; p = 0.021). When identifying the mechanism of ACL injury, there was a higher injury rate in the control group compared with the intervention group for both contact and noncontact mechanisms. For contact ACL injuries, there were fewer injuries in the athletes who used the FIFA 11+ compared with those who did not (0.35% [one of seven] versus 0.90% [six of seven]; RR, 0.21; 95% CI, 0.03-1.74; p = 0.148). For noncontact mechanisms, there were fewer ACL injuries in the athletes who utilized the FIFA 11+ compared with those who did not (0.70% [two of 12] versus 1.5% [10 of 12]; RR, 0.25; 95% CI, 0.06-1.15; p = 0.049), representing a 75% decrease in noncontact ACL injury (Table 2).

Table 1:
Control versus intervention group demographic values
Table 2:
Control versus intervention group comparison chart, injury frequency, percent of total injury, injury rates, RRs with 95% confidence intervals, and p values

With the numbers available, there was no difference between the ACL injury rate within the FIFA 11+ and control groups with respect to game and practice sessions (games—intervention: 1.055% [three of 15] versus control: 1.80% [12 of 15]; RR, 0.31; 95% CI, 0.09-1.11; p = 0.073 and practices—intervention: 0% [zero of four] versus control: 0.60% [four of four]; RR, 0.14; 95% CI, 0.01-2.59; p = 0.186) (Table 2).

With the numbers available, there were no differences associated with player position in either group; the incidence rates for midfielders, defenders, forwards, and goalkeepers in the intervention group were 0.227, 0.085, 0, and 0, whereas in the control group they were 0.54, 0.339, 0.339, and 0, respectively (p = 0.207) (Table 2).

We observed no differences with the numbers available between the ACL injury rates for Division I between groups (intervention: 0.70% [two of nine] versus control: 1.05% [seven of nine]; RR, 0.30; 95% CI, 0.06-1.45; p = 0.136). However, the risk of injury was lower in the intervention group than the control group in Division II athletes (intervention: 0.35% [one of 10] versus control: 1.35% [nine of 10]; RR, 0.12; 95% CI, 0.02-0.93; p = 0.042) (Table 2).

A two-way analysis of variance was conducted to compare the main effects of field type between the intervention group and control group on contact versus noncontact ACL injury. A logistic linear regression (Poisson) analysis was used to compare the number of ACL injuries between groups, intervention versus control, and for field types, grass versus turf, because number of ACL injuries is a count variable and normality was violated for both groups. There was no difference between the number of ACL injuries in the control group versus the intervention group that occurred on grass versus turf (Wald chi square [1] = 0.473, b = 0.147, SE = 0.21, p = 0.492). There were no differences in the number of ACL injuries that occurred on grass between the teams that used the FIFA 11+ versus those that did not (control group: 1.05% [seven of nine] versus intervention group: 0.7% [two of nine]; RR, 0.36; 95% CI, 0.08-1.73; p = 0.201). However, there were more ACL injuries that occurred on artificial turf identified in the control group (1.35% [nine of 10]) versus the intervention group (0.35% [one of 10]; RR, 0.14; 95% CI, 0.02-1.10; p = 0.049; Table 3).

Table 3:
Anterior cruciate ligament injuries by field type


The FIFA 11+ was designed as an injury prevention program to address the most common soccer-related injuries. Unlike other injury prevention programs, the FIFA 11+ was not solely designed to decrease ACL injury [32, 39-41]. To our knowledge, the degree to which the program may effectively reduce the rate of ACL injury has not been examined [30, 37, 44, 47, 50]. This current study demonstrated that the FIFA 11+ program decreased the overall incidence rate of ACL injury by 77% in competitive collegiate male soccer players. There was no difference in ACL injury rates based on grass, games versus practices, in Division I athletes, or between player positions. However, there were fewer ACL injuries incurred in the Division II teams that utilized the FIFA 11+ compared with the control group (p = 0.042). In addition, there were more ACL injuries that occurred on artificial turf identified in the control group compared with the intervention group (p = 0.049).

The study's limitations include that four intervention teams were lost to followup and, therefore, an intent-to-treat analysis was not feasible. A per-protocol analysis was completed, which might inflate the reported benefit to the intervention group. This study only involved male soccer players. The rate of ACL injury in the male collegiate cohort is typically lower than the female injury rate [1, 2, 4]. However, the initial study of the FIFA 11+ was conducted using female soccer players, hence the decision to study the male population in this specific study [47]. In addition, the study has been lacking the statistical power to sufficiently compare ACL injury rates in the various subgroups despite the fact that the study encompassed 1525 athletes participating on 61 collegiate soccer teams. The occurrence of an ACL injury is a relatively rare event, and as a result of the prospective nature of the study design, we were limited in our analysis attributable to the low incidence rate of ACL injury during the data collection period. The analysis comparing ACL injury rates in games and practices, for Division I athletes and for grass injuries, showed no difference compared with the overall ACL injury rate and the overall injury rate reported and analyzed in an earlier publication [46]. Although steps were taken to mitigate team and player contamination to injury prevention program exposure, we were unable to fully account for program exposure that may have occurred in the high school and club soccer setting or in the event that the athlete transferred from another institution.

This study demonstrated a decreased overall risk of ACL injury and noncontact ACL injury in men in the intervention group. The study did not reflect a decrease in contact ACL injury despite the fact that there was only one contact ACL injury reported in the intervention group compared with six in the control group. This may be explained by the fact that ACL injuries, despite their deleterious nature, are a relatively rare event in the sport of soccer, which is evident when analyzing the injury rate.

There was no difference in the male ACL injury rate between groups with respect to player position. This is inconsistent with prior research that has demonstrated that defenders are at a higher risk for ACL injury than other player positions [10, 53]. A recent study highlighted the fact that, on video analysis of ACL injuries occurring in the sport of soccer, 73% of the injuries occurred while defending [10]. An additional study corroborated these findings suggesting that the most common playing situations preceding an ACL injury were defensive in nature 77% of the time: pressing followed by kicking and heading [53]. Ascertaining meaningful knowledge about the incidence of ACL injury based on the specific demands of player positioning may allow researchers to improve existing injury prevention and reduction methods [8, 10, 53].

We did not observe a difference in ACL injury rates between the FIFA 11+ and control teams in Division I soccer, but we did observe fewer ACL injuries among Division II teams that trained using FIFA 11+. Historically, game and practice injury rates have been shown to be lower in Division II and III compared with Division I [34]. This might be attributed to differences in the intensity of play and overall skill level across divisions. This may also represent an important finding on program delivery and overall program efficacy. The FIFA 11+ program was designed to be administered by coaches, parents, or athletes who may or may not have any medical expertise, clinical background, or a biomechanical knowledge base. Division II athletes traditionally are not privy to as many resources as Division I athletes and may not have direct oversight during program delivery by a certified athletic trainer or strength and conditioning coach for every game and training session. Therefore, the data suggest that this program can be effectively implemented without demanding the presence of a licensed medical professional. This has important implications from a public health perspective with respect to cost-effectiveness and the ease of program implementation [7, 49].

Although the overall risk of injury was not greater on turf than on grass, the risk of injury on turf was lower in the group that used FIFA 11+ than the group that did not. Field type has been discussed in prior work and has often been found to be associated with an increased risk of ACL injury in other NCAA sports [15, 16]. Researchers and clinicians should consider the role that field surface may play in addition to friction coefficient from the shoe-surface interface and peak torque measures between the shoe and playing surface [42, 43, 51]. Further clinical investigation is warranted to enhance the understanding of how these variables may affect the rate of ACL injury.

The results of this study demonstrated the ability of the FIFA 11+ to decrease the incidence of ACL injuries in competitive collegiate male soccer players by 77%. This information may have an important impact on the development and advancement of injury prevention protocols and may mitigate risk to soccer athletes who utilize the program. This knowledge can provide critical insight to help reduce the rate of ACL injury in male soccer players, improve the efficacy of existing ACL injury prevention protocols, and improve secondary prevention strategies. Future studies should investigate the efficacy of the FIFA 11+ program with respect to ACL injury prevention in female collegiate players. In addition, the cost-effectiveness of utilizing this prevention program in the collegiate cohort should be analyzed to determine if the cost associated with program implementation is justified.


We thank all of the Division I and Division II NCAA-certified athletic trainers, coaching staffs, and players that participated in this study. We are appreciative of their time, dedication, and compliance to the important body of research.


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