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Patient Age and Hip Morphology Alter Joint Mechanics in Computational Models of Patients With Hip Dysplasia

Thomas-Aitken, Holly D. MS; Goetz, Jessica E. PhD; Dibbern, Kevin N. MS; Westermann, Robert W. MD; Willey, Michael C. MD; Brown, Timothy S. MD

Clinical Orthopaedics and Related Research®: May 2019 - Volume 477 - Issue 5 - p 1235–1245
doi: 10.1097/CORR.0000000000000621
BASIC RESEARCH
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Background Older patients (> 30 years) undergoing periacetabular osteotomy (PAO) to delay THA often have inferior patient-reported outcomes than younger adult patients (< 30 years). It is unclear how patient age affects hip morphology, mechanics, or patient-reported outcome scores.

Questions/purposes (1) Is increased patient age associated with computationally derived elevations in joint contact stresses? (2) Does hip shape affect computationally derived joint contact stresses? (3) Do computationally derived joint contact stresses correlate with visual analog scale (VAS) pain scores evaluated at rest in the clinic at a minimum of 1 year after surgery?

Methods A minimum of 1 year of clinical followup was required for inclusion. The first 15 patients younger than 30 years of age, and the first 15 patients older than 30 years of age, who underwent PAO for treatment of classic dysplasia (lateral center-edge angle < 25°) who met the minimum followup were selected from a historical database of patients treated by a single surgeon between April 2003 and April 2010. The older cohort consisted of 14 females and one male with a median age of 41 years (range, 31-54 years). The younger cohort consisted of 10 females and five males with a median age of 19 years (range, 12-29 years). Median followup for the older than 30 years versus younger than 30 years cohort was 19 months (range, 12-37 months) versus 24 months (range, 13-38 months). Pre- and postoperative hip models were created from CT scans for discrete element analysis (DEA) contact stress computations. DEA treats contacting articular surfaces as rigid bodies (bones) separated by a bed of compressive springs (cartilage), the deformation of which governs computation of joint contact stresses. This technique greatly simplifies computational complexity compared with other modeling techniques, which permits patient-specific modeling of larger cohorts. Articular surface shape was assessed by total root mean square deviation of each patient’s acetabular and femoral cartilage geometry from sphericity. Preoperative and postoperative VAS pain scores evaluated at rest in the clinic were correlated with computed contact stresses.

Results Patients older than 30 years had higher predicted median peak contact stress preoperatively (13 MPa [range, 9-23 MPa; 95% confidence interval {CI}, 11-15 MPa] versus 7 MPa [range, 6-14 MPa; 95% CI, 6-8 MPa], p < 0.001) but not postoperatively (10 MPa [range, 6-18 MPa; 95% CI, 8-12 MPa] versus 8 MPa [range, 6-13 MPa; 95% CI, 7-9 MPa], p = 0.137). Deviation from acetabular sphericity positively correlated with preoperative peak contact stress (R2 = 0.326, p = 0.002) and was greater in the older cohort (0.9 mm [range, 0.8-1.5 mm; 95% CI, 0.8-1.0 mm] versus 0.8 mm [range, 0.6-0.9 mm; 95% CI, 0.7-0.9 mm], p = 0.014). Peak preoperative contact stress did not correlate with preoperative VAS pain score (R2 = 0.072, p = 0.229), and no correlation was found between change in peak contact stress and change in VAS score (R2 = 0.019, p = 0.280).

Conclusions Patients over the age of 30 years with dysplasia had less spherical acetabula and higher predicted preoperative contact stress than those younger than 30 years of age. Future studies with larger numbers of patients and longer term functional outcomes will be needed to determine the role of altered mechanics in the long-term success of PAO varying with patient age.

Clinical Relevance These findings suggest that long-term exposure to abnormal joint loading may have deleterious effects on the hip geometry and may render the joint less amenable to joint preservation procedures. Given the lack of a direct relationship between mechanics and pain, orthopaedic surgeons should be particularly critical when evaluating three-dimensional dysplastic hip morphology in patients older than 30 years of age to ensure beneficial joint reorientation.

H. D. Thomas-Aitken, J. E. Goetz, K. N. Dibbern, Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA

H. D. Thomas-Aitken, J. E. Goetz, K. N. Dibbern, R. W. Westermann, M. C. Willey, T. S. Brown, Department of Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA, USA

T. S. Brown, Department of Orthopedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242-1009, USA, email: timothy-s-brown@uiowa.edu

One or more of the authors (HDT-A, JEG, MCW) received grants from the Orthopaedic Research and Education Foundation.

All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request.

Clinical Orthopaedics and Related Research® neither advocates nor endorses the use of any treatment, drug, or device. Readers are encouraged to always seek additional information, including FDA-approval status, of any drug or device prior to clinical use.

Each author certifies that his or her institution approved the human protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.

Received May 16, 2018

Accepted December 05, 2018

© 2019 Lippincott Williams & Wilkins LWW
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