Experimental Investigation Of The Tissue Reaction To Acrylic PlasticsHenrichsen, E.; Jansen, K.; Krogh-Poulsen, W.; Peltier, Leonard, F.Clinical Orthopaedics and Related Research: July 1998 - Volume 352 - Issue - p 4–6 THE CLASSIC: PDF Only Free Abstract Author InformationAuthors The article, Experimental Investigation of the Tissue Reaction to Acrylic Plastics, was chosen as the classic for this symposium because it represents one of the earliest efforts to determine the biocompatibility of acrylic plastics. The experiment was conducted in the laboratory of the Orthopaedic Hospital in Copenhagen, using methods available at the time. The preliminary conclusions of the experiment were significant. The lack of any observable tissue reaction to the presence of the plastic material provided support and encouragement to orthopaedic surgeons who were anxious to use these materials to address clinical problems. Orthopedic Hospital, Department II, Copenhagen, Chief: Sven Kler, and from the Agricultural Experimental Station, Department of Animal Physiology, Copenhagen, Chief: H. Møllgaard © Lippincott-Raven Publishers.