Secondary Logo

Journal Logo

The Ultrastructure and Biochemistry of Meniscal Cartilage

MCDEVITT, CAHIR, A.*; WEBBER, RICHARD, J.**

Section Editor(s): WEBBER, RICHARD J. PH.D.

Clinical Orthopaedics and Related Research: March 1990 - Volume 252 - Issue - p 8–18
SECTION I: SYMPOSIUM: NEWEST KNOWLEDGE OF THE KNEE JOINT MENISCUS: PDF Only
Free

The meniscus is characterized at the light microscopic and ultrastructural levels by thick collagen fibers that are predominantly circumferential in orientation. The extracellular matrix of the meniscus is composed mainly of collagen, with smaller quantities of proteoglycans, matrix glycoproteins, and elastin. The collagen is predominantly Type I, with smaller quantities of Types II, III, and V. The proteoglycans are mainly large, aggregating proteoglycans with chondroitin sulfate as their dominant glycosaminoglycan. A small proportion of small dermatan sulfate proteoglycans is probably present. The matrix glycoproteins include the link proteins, the 116-k protein, and a group of adhesive or potentially adhesive proteins that includes Type VI collagen (here classified as a glycoprotein with a collagenous domain), fibronectin, and thrombospondin. The fibrochondrocytes of the meniscus appear to have considerable potential to respond to growth and other modulating factors in the repair or regeneration of the tissue.

* From the Department of Musculoskeletal Research, The Cleveland Clinic Foundation Research Institute, Cleveland, Ohio.

** From the Departments of Pathology, Biochemistry/Molecular Biology, and Orthopaedic Surgery, University of Arkansas for Medical Sciences. Little Rock, Arkansas.

Reprint requests to Cahir A. McDevitt, Ph.D., Department of Musculoskeletal Research, The Cleveland Clinic Foundation Research Institute, WB3, Cleveland, OH 44195.

Supported by NIH grants AR39569, AR34349. and ARO1799.

Received: June 5, 1989.

© Lippincott-Raven Publishers.