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Meniscal Replacement Using a Cryopreserved Allograft: An Experimental Study in the Dog

ARNOCZKY, STEVEN, P.; WARREN, RUSSELL, F.; MCDEVITT, CAHIR, A.

Section Editor(s): WEBBER, RICHARD J. PH.D.

Clinical Orthopaedics and Related Research: March 1990 - Volume 252 - Issue - p 121–128
SECTION I: SYMPOSIUM: NEWEST KNOWLEDGE OF THE KNEE JOINT MENISCUS: PDF Only
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The medial menisci of 14 adult dogs were replaced using a cryopreserved meniscal allograft. The morphology and metabolic activity of the transplanted allografts were then evaluated using routine histology, a vascular-injection (Spalteholz) technique, and autoroentgenography (Na235SO4 incorporation) at various intervals, from two weeks to six months postoperatively. After transplantation, the allografts retained their normal gross appearance and healed to the capsular tissues of the host by fibrovascular scar tissue. Histologically, the grafts demonstrated a decrease in the number of metabolically active cells after transplantation but had a normal cellular distribution and Na235SO4 uptake by three months. The allografts appeared to function normally after transplantation. Although some degenerative changes were noted in the tibial articular cartilage not covered by the meniscus, the cartilage beneath the allograft appeared normal.

From the Laboratory of Comparative Orthopaedic Research, Hospital for Special Surgery, affiliated with the New York Hospital, Cornell University Medical College, New York, New York.

Reprint requests to Steven P. Arnoczky, D.V.M., Laboratory of Comparative Orthopaedic Research, Hospital for Special Surgery, 535 E. 70th St., New York, NY 10021.

Supported by the Zimmer Research Award from the Orthopaedic Research and Education Foundation.

Received: June 5, 1989.

© Lippincott-Raven Publishers.