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Evaluation of Musculoskeletal Sepsis with Indium- 111 White Blood Cell Imaging

OUZOUNIAN, TYE, J.*; THOMPSON, LAURA**; GROGAN, THOMAS, J.*; WEBBER, MILO, M.**; AMSTUTZ, HARLAN, C.*

Clinical Orthopaedics and Related Research: August 1987 - Volume 221 - Issue - p 304
Section III BASIC SCIENCE AND PATHOLOGY: PDF Only
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The detection of musculoskeletal sepsis, especially following joint replacement, continues to be a challenging problem. Often, even with invasive diagnostic evaluation, the diagnosis of infection remains uncertain. This is a report on the first 55 Indium-Ill white blood cell (WBC) images performed in 39 patients for the evaluation of musculoskeletal sepsis. There were 40 negative and 15 positive Indium-111 WBC images. These were correlated with operative culture and tissue pathology, aspiration culture, and clinical findings. Thirty-eight images were performed for the evaluation of possible total joint sepsis (8 positive and 30 negative images); 17 for the evaluation of nonarthroplastyrelated musculoskeletal sepsis (7 positive and 10 negative images). Overall, there were 13 true-positive, 39 true-negative, two false-positive, and one false-negative images. Indium-111 WBC imaging is a sensitive and specific means of evaluating musculoskeletal sepsis, especially following total joint replacement.

From the University of California, Los Angeles School of Medicine, Los Angeles, California.

© Lippincott-Raven Publishers.