The Effects of Chymopapain on Prolapsed Human Intervertebral Disc: A Clinical and Correlative Histochemical StudySUGURO, TORU; OEGEMA, THEODORE, R., JR.; BRADFORD, DAVID, S.Clinical Orthopaedics and Related Research: December 1986 - Volume 213 - Issue - p 223–231 SECTION II: GENERAL ORTHOPAEDICS: PDF Only Free Abstract Author InformationAuthors Light and electron microscopy were used to demonstrate extensive matrix degradation in a failed chymopapain-treated disc as compared with an untreated degenerative control disc. Both specimens contained viable cells with patches of degenerative cells. There was a loss of disc height in the chymopapain-treated disc, but no improvement of symptoms. These results illustrated that even in well-circumscribed cases with documented disc protrusion into the spinal canal, the disc space narrowing following injection may aggravate the symptoms of nerve root entrapement, especially if a low-grade lateral recess stenosis is associated with the disc protrusion. The persistence or aggravation of symptoms probably is related to these anatomic considerations. The low level of enzyme activity in the injected area may or may not be correlated with the clinical response to treatment. From the Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, Minnesota. © Lippincott-Raven Publishers.