Estrogens and OsteoarthritisROSNER, ITZHAK, A.; GOLDBERG, VICTOR, M.; MOSKOWITZ, ROLAND, W.Clinical Orthopaedics and Related Research: December 1986 - Volume 213 - Issue - p 77–83 Article: PDF Only Free Abstract Author InformationAuthors Clinical and laboratory observations suggest that a relationship exists between sex hormones and the development of osteoarthritis. The mechanisms whereby these hormones influence the pathophysiology of osteoarthritis have been explored. Tamoxifen, an estrogen antagonist, reduced erosive changes in meniscectomy-induced osteoarthritis in rabbits. By contrast, estradiol worsened it. There was no effect of either agent on the incidence of osteophytes in this model. Both estradiol and tamoxifen affected proteoglycan, prostaglandin, and proteoglycanase production by cartilage components. These observations suggest that cartilage is a sex hormone-sensitive tissue. This may have therapeutic implications in the future. From the Departments of Medicine (Division of Rheumatic Diseases) and Orthopaedic Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio. © Lippincott-Raven Publishers.