SECTION III: BASIC SCIENCE AND PATHOLOGY: PDF OnlyThe Effect of Anorexia Nervosa on Bone Morphometry in Young WomenCROSBY, LON O. PH.D.*; KAPLAN, FREDERICK S. M.D.**; PERTSCHUK, MICHAEL J. M.D.†; MULLEN, JAMES L. M.D.‡Editor(s): URIST, MARSHALL R. M.D., Editor-in-Chief Author Information Departments of Surgery, Orthopaedic Surgery and Psychiatry; Center for Behavioral Medicine and Clinical Nutrition Center, University of Pennsylvania School of Medicine, Philadelphia, PA. Reprint requests to Frederick S. Kaplan, M.D., Two Silverstein, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104. *Research Associate, Department of Surgery. **Assistant Professor of Orthopaedic Surgery. †Associate Professor of Psychiatry. ‡Associate Professor of Surgery. Supported in part by NIH Grant No. 5-M01-RR00040, and also by grants from Smith Kline Beckman and from the University of Pennsylvania Clinical Nutrition Center. Received: April 20, 1984. Clinical Orthopaedics and Related Research: December 1985 - Volume 201 - Issue - p 271-277 Free Abstract Changes in bone morphometry during chronic undernutrition were evaluated in 14 young women with anorexia nervosa (mean age ± SEM = 25.5 ± 4.4 yrs). Bone morphometry studies using the second metacarpal of the left hand showed significant depression for percent cortical area (p < 0.05); cortical area (p < 0.001) and combined cortical thickness (p < 0.01) as compared to age, sex and race matched controls. A trend (p < 0.10) was observed in study subjects for reductions in bone width and total area. Using percent cortical area (PCA) as the standard, subjects had mean cortical bone morphometry equivalent to 60-year-old women. Appendicular bone mass is significantly decreased in adults with anorexia nervosa. Anorexia nervosa should be considered in the differential diagnosis of osteopenia in young women, and serves as a model for studying the effects of chronic calorie and mineral malnutrition on bone remodeling at the time of attainment of peak bone mass. © Lippincott-Raven Publishers.