SECTION I: SYMPOSIUM: ARTHROGRYPOSIS MULTIPLEX CONGENITA: PDF OnlyGenetic Aspects of ArthrogryposisHALL, JUDITH, G.*Section Editor(s): THOMPSON, GEORGE H. M.D. Author Information * Professor of Medical Genetics, University of British Columbia, Vancouver, British Columbia. Reprint requests to Judith G. Hall, M.D., UBC Clinical Genetics Unit, Grace Hospital, 4490 Oak Street, Vancouver, British Columbia, Canada V6H 3V5. Supported in part by The March of Dimes. Received: August 8, 1984. Clinical Orthopaedics and Related Research: April 1985 - Volume 194 - Issue - p 44-53 Free Abstract Multiple congenital contractures or arthrogryposis is a birth defect that occurs in approximately one in 3000 births. It can be seen in isolation or in association with other abnormalities. The etiologic and genetic basis of multiple congenital contractures is very heterogeneous. In order to understand the genetic basis and natural history of a specific case, a specific diagnosis must be made. Over 150 conditions are known in which multiple congenital contractures are a predominant sign. In this chapter, the emphasis is on a systematic differential diagnosis and consideration of empiric recurrent risk figures if a specific diagnosis cannot be reached. © Lippincott-Raven Publishers.