Section III: BASIC SCIENCE AND PATHOLOGY: PDF OnlyHydrogen Peroxide as a Topical Hemostatic AgentHANKIN, FRED M. M.D.; CAMPBELL, SCOTT E. B.S.; GOLDSTEIN, STEVEN A. PH.D.; MATTHEWS, LARRY S. M.D.Editor(s): URIST, MARSHALL R. M.D, Editor-in-Chief Author Information Biomechanics, Trauma and Sports Medicine Laboratory, Section of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan. Reprint requests to Steven A. Goldstein, Ph.D., Section of Orthopaedic Surgery, University of Michigan Medical Center, C-4002 Outpatient Building, 1405 East Ann Street, Ann Arbor, MI 48109. Supported, in part, by Medical Science, Research and Education Grant #30-81, Wayne County General Hospital, Westland, Michigan, and by the Zimmer Corporation, Warsaw, Indiana. Received: July 5, 1983. Clinical Orthopaedics and Related Research: June 1984 - Volume 186 - Issue - p 244-248 Free Abstract Many research efforts have been directed toward enhancing the bone-cement interface of total joint arthroplasties. Hemostatic agents have been popularized as effective means of retarding the development of potentially harmful debris interposition adjacent to, and blood lamination patterns within, the methylmethacrylate. The hemostatic effectiveness of hydrogen peroxide was tested on six metaphyseal bone beds in ten mongrel dogs: three sites were treated with hydrogen peroxide and three were saline-treated control sites. The hemostatic effect of the treatments was determined by comparing blood loss per unit area per minute before and after application of the test solutions. The results indicate that hydrogen peroxide is an effective hemostatic agent and reduces the amount of blood and debris trapped within the trabecular bone methylmethacrylate interface. © Lippincott-Raven Publishers.