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Simultaneous Multifocal Sarcomatous Degeneration in Paget's Disease of Bone A Hypothesis

Choquette, D.*; Haraoui, B.*; Altman, R., D.**; Pelletier, J., P.

Clinical Orthopaedics and Related Research: October 1983 - Volume 179 - Issue - p 308
Section III: BASIC SCIENCE AND PATHOLOGY: PDF Only
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Multisite pagetic sarcoma was present in three of 18 patients with pagetic sarcomas treated during a 12-year period at two centers. A hypothesis of multifocal origin of the tumor is supported by the sarcoma arising only in pagetic bone, the infrequency of metastases to bone, evidence of multiple sites at presentation, and the rarity of new lesions developing in bone under observation. Survival was shorter with multisite disease than with other pagetic sarcomas.

* Senior Rheumatology Fellow, Montreal University, Rheumatic Disease Unit, Notre-Dame Hospital, Montreal, Quebec, Canada.

** Professor of Medicine, School of Medicine, University of Miami School of Medicine and Chief Arthritis, Miami VA Medical Center, Miami, Florida.

Assistant Professor of Medicine, University of Montreal, Rheumatic Disease Unit, Notre-Dame Hospital, Montreal, Quebec, Canada.

© Lippincott-Raven Publishers.