Confirming earlier work by other investigators in isolated chondrocyte cultures, prostaglandin E2 (PGE2) (25 μg/ml) causes rapid inhibition of in vitro articular cartilage proteoglycan synthesis in adult pig cartilage slices. The potential impact of E prostaglandins on articular cartilage should be considered in clinical situations associated with elevated intra-articular prostaglandin levels (trauma, meniscal injury, arthritis, etc.).
* Assistant Professor of Surgery (Orthopaedics), University of Connecticut School of Medicine, Farmington, Connecticut.
** Research Assistant, Orthopaedic Cartilage and Connective Tissue Laboratory, University of Connecticut School of Medicine, Farmington, Connecticut.