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Effect of Prostaglandin E2 on Adult Pig Articular Cartilage Slices in Culture

Fulkerson, John, P.*; Damiano, Patricia**

Clinical Orthopaedics and Related Research: October 1983 - Volume 179 - Issue - p 266–269
Section III: BASIC SCIENCE AND PATHOLOGY: PDF Only
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Confirming earlier work by other investigators in isolated chondrocyte cultures, prostaglandin E2 (PGE2) (25 μg/ml) causes rapid inhibition of in vitro articular cartilage proteoglycan synthesis in adult pig cartilage slices. The potential impact of E prostaglandins on articular cartilage should be considered in clinical situations associated with elevated intra-articular prostaglandin levels (trauma, meniscal injury, arthritis, etc.).

* Assistant Professor of Surgery (Orthopaedics), University of Connecticut School of Medicine, Farmington, Connecticut.

** Research Assistant, Orthopaedic Cartilage and Connective Tissue Laboratory, University of Connecticut School of Medicine, Farmington, Connecticut.

© Lippincott-Raven Publishers.