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Gabapentin Supplemented With Ropivacain Block of Trigger Points Improves Pain Control and Quality of Life in Trigeminal Neuralgia Patients When Compared With Gabapentin Alone

Lemos, Laurinda MD* †; Flores, Sara; Oliveira, Pedro PhD; Almeida, Armando PhD*

The Clinical Journal of Pain: January 2008 - Volume 24 - Issue 1 - p 64-75
doi: 10.1097/AJP.0b013e318158011a
Original Articles

Objective Pain control in trigeminal neuralgia (TN) is achieved using anticonvulsivants, mainly carbamazepine. When this drug cannot be used, other drugs like gabapentin (GBP) have been used to provide adequate pain control. To improve the therapeutic effect of GBP, we evaluated the clinical efficacy of associating GBP with ropivacain (ROP) analgesic block of facial trigger points in TN patients.

Design Thirty-six TN patients were randomly assigned during 4 weeks to 1 of the following protocols: Protocol I—daily oral GBP administered in a titrated dose; Protocol II—ROP applied as analgesic block to TN trigger points once a week; Protocol III—daily oral GBP plus ROP once a week. Protocol II had to be discontinued in 7/12 patients owing to insufficient pain control. Pain intensity was evaluated by the Visual Analog Scale (VAS) and disability was assessed by Sickness Impact Profile.

Results When compared with Protocol I, Protocol III (GBP+ROP) patients showed (1) a reduction of VAS score after 7 and 28 days of treatment, an effect that was still present 6 and 12 months later; (2) a faster reduction of VAS score using a significantly lower dose of GBP; (3) a smaller total and daily GBP dose at the end of the treatment, which resulted in a total absence of adverse side effects; and (4) an improvement of the functional well-being measured by the Sickness Impact Profile. The number needed to treat (NNT) (GBP+ROP vs. GBP protocols) to obtain 1 GBP+ROP-treated patient with at least 50% pain relief was 1.71 (day 7) and 2.40 (day 28).

Conclusions The association of GBP and ROP is safe, without side effects and results in an important clinical benefit associated to an improvement of the functional health status of TN patients when compared with GBP alone. This may constitute a therapeutic alternative for pain control in TN patients who cannot be treated with carbamazepine.

*Health and Life Sciences Research Institute (ICVS), School of Health Sciences

Production and Systems Engineering, University of Minho, Braga

Hospital Center of Alto Ave, Unit of Fafe, Fafe, Portugal

Supported by Fundação para a Ciência e Tecnologia (FCT) Project no POCTI/NSE/46399/2002, FEDER and Fundação Calouste Gulbenkian Project no. 74551.

Reprints: Prof Armando Almeida, PhD, Health and Life Sciences Research Institute, School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal (e-mail:

Received for publication April 16, 2007; revised July 30, 2007; accepted August 8, 2007

© 2008 Lippincott Williams & Wilkins, Inc.