Notable sources of exclusion were as follows (note that some citations could fall within more than 1 category but for clarity of reporting are described in the most applicable category): (1) nonrandomized design including case studies investigating exposure-based interventions (n=37)21,53–88 or case series (n=5)31,89–92; (2) incorrect population including RCTs with children with nonspecific phobias (n=2; eg, social phobia, agoraphobia)93,94 or adults with general or global dental fear, which is seen as a distinct issue29 (n=2)95,96; (3) incorrect population including muscle tension techniques explored in nonfearful populations (n=3),97–99 as well as a series of studies examining the muscle tension technique in voluntary blood donors (individuals who would volunteer to give blood are seen as unlikely to have high levels of needle fear100; n=9)101–109; (4) insufficient levels of fear, unsystematic screening process, or the potential that the fear was adaptive (ie, presence of a fear of water when it was unclear whether participants knew how to swim; n=3)110–112; and (5) treatment did not match clinical questions, dismantling trials, or no relevant outcomes (n=21).113–133
Treatment was delivered in a single session ranging between 2.5 and 3 hours in 4 of the studies40–42,46 and 4 hours in the remaining study.45 All the treatments were modeled after Öst’s28 “One session treatment” and included modeling and hierarchical exposure to the feared stimuli; 4 of the trials40–42,45 specified some degree of cognitive restructuring or targeting of the catastrophic cognition. Comparison groups were waitlist control40–42,45 or a “placebo” group of a computerized exposure to spiders.46 In vivo exposure-based therapy demonstrated benefit on specific fear (4 trials; n=235; SMD: −1.71 [95% CI: −2.72, −0.7]) (Table, Supplemental Digital Content 1, http://links.lww.com/CJP/A225 and Figure, Supplemental Digital Content 7, http://links.lww.com/CJP/A231). Important outcomes with data shown in the supplemental digital content (Table, Supplemental Digital Content 1, http://links.lww.com/CJP/A225 and Figure, Supplemental Digital Content 7, http://links.lww.com/CJP/A231) include general fear, compliance (using a BAT), child satisfaction, and parent satisfaction.
Two trials with 93 adults who were fearful of injections were included in this analysis comparing multiple and single sessions of in vivo exposure.48,49 Participants met the diagnostic criteria for specific phobia according to the version of the Diagnostic and Statistical Manual of Mental Disorders that was in use at the time of the study. According to study descriptions, both treatments followed Öst’s treatment principles28,42; in vivo exposure consisted of either preparation, rehearsal, hierarchical exposure to feared stimuli,48 or hierarchical exposure to feared stimuli targeting focus of catastrophic beliefs.49 Multiple-session in vivo exposure was given over 5 weekly 1 hour sessions in both trials; the 1 session treatment was maximized to 3 hours in 1 trial48 but the length of time was not reported for the other trial.49 Results were mixed for the critical outcome of specific fear (Table, Supplemental Digital Content 3, http://links.lww.com/CJP/A227 and Figure, Supplemental Digital Content 9, http://links.lww.com/CJP/A233). Multiple-session in vivo exposure-based therapy was superior to single session exposure for the reduction of specific fear measured posttreatment (n=93; SMD: −0.66 [−1.08, −0.24]) but not at 1-year follow-up (n=83; SMD: −0.37 [−0.87, 0.13]). Data for the following important outcomes measured at 2 time-points (posttreatment, 1-year follow-up) are presented in the supplemental digital content (Table, Supplemental Digital Content 3, http://links.lww.com/CJP/A227 and Figure, Supplemental Digital Content 9, http://links.lww.com/CJP/A233): general fear, compliance (using a BAT), and fainting. Compliance with a voluntary blood donation or voluntary dental injection over the 12-month follow-up period is also summarized.
This systematic review and meta-analysis is the first to examine the efficacy of exposure-based interventions for the reduction of fear in individuals with high levels of needle fears or phobias across the lifespan. Consideration of this vulnerable population within the context of vaccine injections is critical given their heightened risk for fears and avoidance of medical care over their lifetime2–15,17,29,136 and complements the other systematic reviews on vaccine pain management in this series.137–142
There were no trials examining interventions specific to the vaccination context (which is perhaps not surprising given that these interventions need to take place outside of this context) and limited trials of children with high levels of needle fears or phobias, requiring us to include indirect evidence from nonvaccination and non-needle contexts. To our knowledge, there has been no published systematic examination of high levels of fear with regard to different types of needle procedures. The included trials enrolled participants with elevated fear of a particular situation, object (typically related to needles), or both and utilized interventions that exposed them to their particular fear. Findings suggest that in vivo exposure-based therapy is effective for reducing specific fear in children (7 y and above) and adults. Among adults with high levels of needle fears, there was limited efficacy found for the superiority of delivering in vivo exposure in multiple, shorter sessions (eg, 5×1 h) as compared with 1 relatively long session (eg, 3 h). Non in vivo (imaginal, computer-based) exposure was also found to have benefit on specific fear among children and adults. Finally, among adults, applied tension (exposure+muscle tension) was found to have additive beneficial effects on fainting, over and above exposure alone. Taken together, these findings support the use of these exposure-based interventions for reducing fear and fainting, respectively, among individuals with high levels of needle fears or phobias.
Overall, there was a striking dearth of research examining interventions for individuals with high levels of needle fears or phobias. We included children and adults with high levels of needle fear and or phobias undergoing vaccination or other needle procedures, followed by the next closest context. We included individuals with a diagnosis of blood-injection-injury phobia or another related phobia (eg, injection phobia) as well as individuals with high levels of needle fear and related functional impairment (eg, being unable to self-inject medicine for their chronic illness management). There were limited trials of blood-injection-injury phobia in adults and no trials in children. In the absence of randomized or quasi-randomized controlled trials on individuals with high levels of needle fears or phobias, we were required to rely on trials of individuals with specific phobias that were unrelated to needles (eg, spider and darkness phobias). Although only occurring for children, this may threaten the generalizability of the current findings to needle contexts. Indeed, individuals with phobias and high levels of fear are not a homogenous group and their response to feared stimuli and intervention are invariably influenced by the specific catastrophic cognitions underlying their fears. In short, extrapolating findings from non–needle-related contexts to the vaccination context is potentially problematic. Nevertheless, this systematic review offers important, new knowledge about effective fear management in this vulnerable group that can be applied to vaccination to guide future research in this area.
Pain was not included as an outcome in the included trials (due to the indirectness of the evidence) but has important implications for needle fears and should be included in future research. The relationship between needle pain and fear is likely reciprocal and should be further delineated. An exploration of the likely complex etiology of needle fears is presented elsewhere in this series.20 However, most individuals with high needle fears or phobias can root their fear back to 1 traumatic needle procedure in their past.29,155,156 Early vicarious and instrumental learning processes may make individuals more vulnerable to experiencing and perceiving greater pain during needle procedures.20,157 Conversely, individuals whose pain is poorly managed during needle procedures are more likely to develop increasingly fearful memories of the procedure158 that then places them at risk for experiencing more distress at subsequent needle procedures.159 This can fuel a vicious self-perpetuating cycle of increased needle fear and pain over time.157 Effective pain management may serve to help prevent needle fears from developing. In short, effective management of pain and fear may serve to reduce future fear and pain and hold promise for preventing distress and impairment (eg, noncompliance) over time. Given that concerns about pain and fear are known contributors to vaccine hesitancy,12,16 effective management of both is paramount.
Consideration of the strengths and limitations of this body of work creates clear pathways for future research. High-quality RCTs of exposure-based interventions with individuals with high levels of needle fear are critically needed, for the vaccination context and otherwise. Ideally, these trials should: (1) enroll sufficient numbers of participants in narrow age ranges to adequately capture developmental differences; (2) assess and report fainting history as well as the specific focus of the needle fear (eg, pain from the needle, injection of a foreign substance) both at baseline and in response to treatment; (3) clearly report and connect the target(s) of the exposure with the focus of the needle fear; and (4) continue to gather longitudinal data as well as expanding the outcomes and follow-up time frame if possible (eg, beyond 1 y) with and without booster sessions. Discussion of implementation considerations is beyond the scope of the present paper and the reader is directed to our clinical practice guideline on the management of high levels of needle fear that explores these issues in detail160; however, future research should also be conducted on various delivery methods of these interventions to enhance feasibility and uptake.
In conclusion, we applied a rigorous methodological approach to conduct the first systematic review of exposure-based interventions for the reduction of fear in individuals of all ages with high levels of needle fears or phobias. No trials specifically examined interventions implemented in the vaccination context and trials of individuals with high levels of needle fears or phobias were limited. Support was found for the efficacy of in vivo and non in vivo exposure therapy for reducing specific fear in individuals with high levels of needle fears or phobias. Multiple sessions of in vivo exposure were not clearly superior to single sessions. Applied tension was efficacious for reducing fainting in adults. These findings suggest that these interventions hold promise for reducing vaccine injection fear in individuals who are particularly vulnerable for experiencing fear and avoidance of medical care over time.
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