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A Narrative Review of the Evidence on the Efficacy of Dexamethasone on Postoperative Analgesic Consumption

Batistaki, Chrysanthi MD, PhD*; Kaminiotis, Evagelia MD*; Papadimos, Thomas MD, PhD; Kostopanagiotou, Georgia MD, PhD*

doi: 10.1097/AJP.0000000000000486
Review Article

Objectives: The effect of dexamethasone on analgesic consumption has not been adequately studied. The aim of this review was to investigate recent literature regarding the possible effect of dexamethasone on postoperative analgesic consumption.

Methods: Critical review of randomized trials and prospective consecutive studies investigating the postoperative analgesic effect of dexamethasone was performed. Only studies published during 2006 to 2015 were included.

Results: Forty-one studies met the inclusion criteria; 33 in adults and 8 in children (9 in general surgery, 8 in gynecologic/breast surgery, 8 in orthopedic/spinal surgery, 8 in head/neck surgery, 7 in children’s tonsillectomy, and 1 in children’s orchiopexy). Literature review demonstrated that dexamethasone can decrease analgesic requirements in patients undergoing laparoscopic cholecystectomies, laparoscopic gynecologic and breast surgery; whereas there is no consensus regarding orthopedic procedures, with positive evidence mostly regarding spinal surgeries. The efficacy of dexamethasone during head and neck surgery is not conclusive; however, its use before thyroid surgery may be beneficial. In children a beneficial impact of dexamethasone administration was revealed on posttonsillectomy reduction of analgesic needs. Studies on other kinds of operations in children are lacking.

Conclusions: Dexamethasone administered at a dose of 8 mg before surgical incision may be beneficial in laparoscopic cholecystectomies, thyroid, laparoscopic gynecologic and breast surgery, and tonsillectomies in children. Dexamethasone’s potential impact on reducing postoperative analgesic requirements should be investigated in more detail in a systematic manner, to support its use in other kinds of operations.

*2nd Department of Anesthesiology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, Greece

Department of Anesthesiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH

Conflicts of interest: None declared.

Reprints: Chrysanthi Batistaki, MD, PhD, 2nd Department of Anesthesiology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” Hospital, 1 Rimini str 124 62, Athens, Greece (e-mail:

Received September 22, 2016

Received in revised form December 27, 2016

Accepted January 27, 2017

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