Modern Palliative Treatments for Metastatic Bone Disease: Awareness of Advantages, Disadvantages, and Guidance : The Clinical Journal of Pain

Secondary Logo

Journal Logo

Review Articles

Modern Palliative Treatments for Metastatic Bone Disease

Awareness of Advantages, Disadvantages, and Guidance

Mavrogenis, Andreas F. MD; Angelini, Andrea MD; Vottis, Christos MD; Pala, Elisa MD; Calabrò, Teresa MD; Papagelopoulos, Panayiotis J. MD, DSc; Ruggieri, Pietro MD, PhD

Author Information
The Clinical Journal of Pain 32(4):p 337-350, April 2016. | DOI: 10.1097/AJP.0000000000000255



Metastatic disease is the most common malignancy of the bone. Prostate, breast, lung, kidney, and thyroid cancer account for 80% of skeletal metastases. Bone metastases are associated with significant skeletal morbidity including severe bone pain, pathologic fractures, spinal cord or nerve roots compression, and malignant hypercalcemia. These events compromise greatly the quality of life of the patients. The treatment of cancer patients with bone metastases is mostly aimed at palliation.


This article aims to present these palliative treatments for the patients with bone metastases, summarize the clinical applications, and review the techniques and results.


It gives an extensive overview of the possibilities of palliation in patients with metastatic cancer to the bone.

Results and Discussion: 

Currently, modern treatments are available for the palliative management of patients with metastatic bone disease. These include modern radiation therapy, chemotherapy, embolization, electrochemotherapy, radiofrequency ablation, and high-intensity focused ultrasound. As such it is of interest for all physicians with no experience with these developments to make palliative procedures safer and more reliable.

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

You can read the full text of this article if you:

Access through Ovid