Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Painful Restless Legs Syndrome: A Severe, Burning Form of the Disease

Karroum, Elias G. MD, PhD*,†,‡; Golmard, Jean-Louis MD, PhD†,§; Leu-Semenescu, Smaranda MD*,‡; Arnulf, Isabelle MD, PhD*,†,‡

The Clinical Journal of Pain: May 2015 - Volume 31 - Issue 5 - p 459–466
doi: 10.1097/AJP.0000000000000133
Original Articles
Buy
SDC

Objectives: Limb sensations in restless legs syndrome (RLS) include an urge to move, a discomfort, or even a frank pain. However, no large studies compared painful to nonpainful RLS as specific phenotypes. We investigated the painful form of RLS in a clinical series of primary RLS patients and a large sample of members of the French RLS association (AFE).

Materials and Methods: Fifty-six patients with primary RLS (face-to-face interviewed) and 734 AFE members (received by ground mail an self-report questionnaire) responded to the presence/absence of painful RLS sensations and were included. They completed a French reconstruction of the McGill Pain Questionnaire (Questionnaire Douleur de Saint-Antoine [QDSA]) to assess their RLS sensations as well as questions about demographics and clinical RLS features.

Results: Sixty-one percent of interviewed patients and 55% of AFE members had painful RLS sensations. The patients with painful RLS were more sleepy and tired than those with nonpainful sensations. The RLS severity and need for current, dopaminergic treatment were higher in AFE members with painful than with nonpainful RLS. In both the groups, the QDSA qualifier “burning” was the most frequent (37% to 44%) sensory discriminator of painful RLS. In the AFE sample, QDSA scores, and the distribution of words in all QDSA subclasses was skewed toward a more severe connotation with more than one third of patients selecting affective discriminating words like “exasperating,” “exhausting,” and “unbearable.”

Discussion: Painful RLS appears to be a severe, “burning” subtype of RLS, and could be a distinct disease or a clinical variant in a sensations continuum.

Supplemental Digital Content is available in the text.

*Sleep Disorder Unit

§Department of Biostatistics, Pitié-Salpêtrière University Hospital

Pierre and Marie Curie University

Brain and Spinal Cord Research Institute (CRICM)-UPMC/Inserm U1127/CNRS UMR7225, Paris, France

Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website, www.clinicalpain.com.

Supported by a grant from the French RLS association (Association France Ekbom, AFE, Strasbourg, France) to E.G.K. S.L.-S. was a paid speaker for UCB Pharma. I.A. was a paid speaker and consultant for UCB Pharma and Jazz Pharmaceuticals, and investigator plus coordinator for Bioprojet. The remaining authors declare no conflict of interest.

Reprints: Isabelle Arnulf, MD, PhD, Service des Pathologies du Sommeil, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l’Hôpital, 75651 Paris Cedex 13, France (e-mail: isabelle.arnulf@psl.aphp.fr).

Received February 9, 2014

Received in revised form July 14, 2014

Accepted June 16, 2014

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.