Special Topic Series Management of Complex Regional Pain SyndromeManagement of Pediatric Patients With Complex Regional Pain SyndromeWilder, Robert T. MD, PhDAuthor Information Mayo Clinic Mayo Eugenio Litta Children's Hospital Reprints: Robert T. Wilder, Mayo Eugenio Litta Children's Hospital, Mayo Clinic, Rochester, MN 55902 USA (e-mail: [email protected]). Received for publication July 25, 2005; accepted July 25, 2005 The Clinical Journal of Pain: June 2006 - Volume 22 - Issue 5 - p 443-448 doi: 10.1097/01.ajp.0000194283.59132.fb Buy Metrics Abstract This review summarizes current information about diagnosis and treatment of complex regional pain syndrome (CRPS) in children. Although it has been widely held that CRPS in children is intrinsically different from adults, there appear to be relatively few differences. However, there is a marked preponderance of lower extremity cases in children. Historically, psychological factors have been invoked to explain the genesis and persistence of CRPS in children, but the evidence is not compelling. Treatment outcome studies are limited but indicate that children generally respond to a primary focus on physical therapy. Multidisciplinary treatment reports are particularly encouraging. The general perception that children have a milder course may relate to the potentially greater willingness of children to actively participate in appropriately targeted treatment rather than to innate differences in the disease process itself. Recurrence rates appear higher than in adults, but response to reinitiation of treatment seems to proceed efficiently. Clinical judgment dictates the extent of medication or interventional therapy added to the treatment to facilitate rehabilitation. In many ways, the approach to the treatment of children mirrors that of adults, with perhaps greater restraint in the use of medications and invasive procedures. The rehabilitation of children with CRPS, like that of adults with CRPS, needs further rigorous investigation. © 2006 Lippincott Williams & Wilkins, Inc.