Short ReportThe Cholecystokinin Antagonist Proglumide Enhances the Analgesic Effect of DihydrocodeineMcCleane, Gary J. MD Author Information Rampark Pain Centre, Lurgan, Northern Ireland, United Kingdom Received December 12, 2001; accepted March 10, 2003. Reprints: Gary J. McCleane, Rampark Pain Centre, 2 Dromore Road, Lurgan, Northern Ireland, United Kingdom. E-mail: [email protected] The Clinical Journal of Pain: May 2003 - Volume 19 - Issue 3 - p 200-201 Buy Abstract Aim To investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine. Method A double-blind, placebo-controlled crossover study of 30 adult subjects. Results Mean pain scores fell from a baseline of 8.12–7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P < 0.05). Side effects were minor. Conclusion The CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine. © 2003 Lippincott Williams & Wilkins, Inc.
