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The Cholecystokinin Antagonist Proglumide Enhances the Analgesic Effect of Dihydrocodeine

McCleane, Gary J. MD

Short Report

Aim To investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine.

Method A double-blind, placebo-controlled crossover study of 30 adult subjects.

Results Mean pain scores fell from a baseline of 8.12–7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P < 0.05). Side effects were minor.

Conclusion The CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine.

Rampark Pain Centre, Lurgan, Northern Ireland, United Kingdom

Received December 12, 2001; accepted March 10, 2003.

Reprints: Gary J. McCleane, Rampark Pain Centre, 2 Dromore Road, Lurgan, Northern Ireland, United Kingdom. E-mail:

© 2003 Lippincott Williams & Wilkins, Inc.