Articles: PDF OnlyMechanisms of Central PainNurmikko, Turo J. M.D., Ph.D.Author Information Pain Research Institute, University Department of Neurological Science, The Walton Centre for Neurology and Neurosurgery NHS Trust, Liverpool, England Address correspondence to Dr. T.J. Nurmikko, Pain Research Institute, University Department of Neurological Science, The Walton Centre for Neurology and Neurosurgery NHS Trust, Liverpool, England L9 7LJ; e-mail: [email protected] The Clinical Journal of Pain: June 2000 - Volume 16 - Issue 2 - p S21-S25 Buy Abstract Central pain is common in patients with stroke, multiple sclerosis, syringomyelia, and spinal cord injury. It frequently develops after a delay of weeks or months, is associated with sensory change involving the spinothalamic pathways, and has a poor prognosis for spontaneous remission. Hypotheses to explain the varied clinical manifestations can be divided in two categories: those stressing aberrant neural activity in the deafferented circuits and those focusing on the postlesion imbalance between facilitatory and inhibitory neural pathways. All models inherently assume a degree of specialization of cerebral structures in pain processing, which has not been proved conclusively. © 2000 Lippincott Williams & Wilkins, Inc.