Alcohol has had a long-standing role in culture over time in relation to social connectedness and relaxation. However, overconsumption is linked to a multitude of serious health and social problems, including adverse events such as motor vehicle crashes, violence, unemployment, broken relationships, and unstable housing. In the United States, alcohol misuse contributes to 88,000 deaths a year and 1 in 10 deaths in working adults.1 Alcohol misuse cost the United States $223.5 billion in 2006, with three quarters of the economic cost and half of the reported deaths from binge drinking.2 In 2010, the annual cost in the United States had increased to $250 billion, with $5.5 billion (or 2.2% of the cost) related to drinking in pregnancy.3 Alcohol misuse impacts individuals of all ages, socioeconomic statuses, and races, with some of these individuals also partaking in other illicit substances.
Of concern, alcohol use in pregnancy remains common with the global prevalence of alcohol use in pregnancy from 1984 to 2014 estimated to be 9.8%4 with rates of use varying depending on the country where the woman resides. According to an international multicenter cross-cohort comparison, the rates of alcohol use in pregnancy ranged from 20% to 80% in Ireland and 40% to 80% in Australia, New Zealand, and the United Kingdom.5 In the United States, the prevalence of any alcohol use amongst women 18 to 44 years of age was found to be 53.6%, with the prevalence of binge drinking 18.2%.6 Among pregnant women, the prevalence of any alcohol use was 10.2% and the prevalence of binge drinking 3.1%, with 1 in 10 of these women reporting alcohol use within the last 30 days and 1 in 33 reporting binge drinking during pregnancy.6 The 2002-2009 Pregnancy Risk Assessment Monitoring System data set showed that in that sample, 49.4% of women reported drinking alcohol before pregnancy and that among these women, ∼87% quit during pregnancy, 6.6% of women reduced their intake, and 6.4% did not change their intake.7
These statistics are in stark contrast with the Surgeon General recommendations in the United States. In 1981, US Surgeon General Edward Brandt advised women who were pregnant or considering pregnancy to limit the amount of alcohol they drank.8 In 2005, Surgeon General Richard Carmona recommended abstinence from alcohol for pregnant women and women who may become pregnant to eliminate the risk of giving birth to an infant affected by fetal alcohol spectrum disorders (FASD). This recommendation was made in the setting of no known safe amount of alcohol in pregnancy. If a woman had already consumed alcohol in pregnancy, the recommendation was to stop to minimize further risk.9
Alcohol use in pregnancy poses specific risks to a developing fetus and is linked with adverse perinatal outcomes, which are likely more common than previously reported. Half of all pregnancies in the United States are unintended,10 so a fetus may be exposed to alcohol in utero at important times in embryologic development even before a woman knows that she is pregnant. Alcohol use during pregnancy is a leading, preventable cause of birth defects and developmental disabilities in the United States, with fetal alcohol syndrome (FAS) being one of the most severe outcomes. Other adverse health effects associated with alcohol use in pregnancy include miscarriage, preterm labor, intrauterine growth restriction, and stillbirth, which all add morbidity to any potential underlying disability.11,12 Alcohol use in reproductive-aged women, and in pregnancy more specifically, remains a public health priority in the United States and abroad. Women are often motivated to make changes in pregnancy and therefore health care providers, especially obstetricians, play an important role in screening, educating, and intervening.
Definitions and Classifications
A standard alcoholic drink can differ in different countries but in the United States and Canada, it is equivalent to 0.6 fL oz of pure ethanol.13–16 This is approximately the amount of ethanol in a 12 oz beer or wine cooler, 5 oz of table wine, 8 to 9 oz malt liquor, or 1.5 oz of 40% spirit13,14 (Table 1).
The National Institute on Alcohol Abuse and Alcoholism defines at-risk alcohol use for healthy nonpregnant women as >3 drinks per occasion or >7 drinks per week and any amount of drinking for women who are pregnant or at risk of pregnancy.
MODERATE OR BINGE DRINKING
The United States Drug Administration classifies moderate drinking in women as 1 drink per day.13 Binge drinking, however, is defined as >3 drinks per occasion for women or alcohol consumption that results in a blood alcohol concentration of 0.08% or above.15 Interestingly, almost half of binge drinking occurs in moderate drinkers.17
Recommendations for Drinking in Pregnancy
Alcohol readily crosses the placenta with fetal blood alcohol levels approaching maternal levels within 2 hours of maternal intake. As there is known safe level of alcohol consumption during pregnancy, and alcohol is a known teratogen that can impact fetal growth and development during all stages of pregnancy, the current recommendation from the American College of Obstetricians and Gynecologists, Center for Disease Control (CDC), Surgeon General, and medical societies from other countries including the Society of Obstetricians and Gynecologists of Canada all recommend complete abstinence during pregnancy.14–16,18,19
Populations at Greatest Risk
The 2013 Substance Abuse and Mental Health Services Administration survey found that of women who consume alcohol during pregnancy, those at greatest risk for alcohol use disorder were most likely American Indian and Alaska Native women (13.7%) compared with white non-Hispanic women (5.6%), Hispanic or Latino women (3.8%), and black non-Hispanic women (3.5%).20 Interestingly, the CDC surveillance system noted, between 2011 and 2013, that the characteristics associated with the highest prevalence of prenatal alcohol use were age between 35 and 44 (18.6%), non-Hispanic black (13.9%), college degree (13%), and employment (12%).6 These women were also more likely to reduce than quit their alcohol use while women who were black or Hispanic, were overweight or obese or multiparas were more likely to quit than reduce their prenatal alcohol consumption. Interestingly, a pregnant woman reported a higher frequency of binge drinking than nonpregnant women. Of women drinking in late-pregnancy, a previous large survey found that the highest prevalence was among women who are white non-Hispanic, college graduates, and aged 35 years or older.21 The hypothesis for these findings was that women who were older and/or more educated had greater discretionary income and those who attended college might have a greater acceptance of alcohol consumption and binge drinking. Unfortunately, these groups of women are also those whom health care providers report having the least screening and counseling for alcohol use.21 The presence of social stressors also seemed to correlate with ongoing alcohol use during the third trimester of pregnancy.7
In regards to binge drinking during pregnancy, the most significant demographic factor was nonmarried status, likely secondary to a multitude of socioeconomic factors, with a prevalence of 4.6 times greater than married pregnant women.6 Of those who binge drank while pregnant, there was a significantly higher frequency of binge drinking (4.6 vs. 3.1 episodes) and greater alcohol consumption per episode (7.5 vs. 6 drinks) compared with nonpregnant binge drinkers.6
Of women who drink in pregnancy, for unclear reasons, there is an increased risk of FAS in those who are of older maternal age, high parity, and African American or Native American ethnicities.19,22
Adverse Maternal Outcomes From Alcohol Consumption
Although men are more likely to drink alcohol and in larger quantities, women have a greater absorption and slower metabolism than men and thus, upon drinking equal amounts, women will have higher blood alcohol levels than men. In addition, women will more likely have long-term health problems from drinking than men23 such as liver disease, including cirrhosis,24 memory loss,25,26 decreased brain volume,25,26 cardiomyopathy,27 and cancer of the mouth, throat, esophagus, liver, colon, and breast.28–31 Women who engage in heavy drinking or chronic alcohol abuse have also been shown to have reduced fertility and a higher rate of menstrual disorders.32–34
Fetal and Neonatal Effects of Maternal Alcohol Consumption
It is challenging to assess a dose-response relationship between the quantity of alcohol consumed prenatally and the effect on fetal and neonatal outcomes. This difficulty stems from the variability in maternal alcohol clearance rates, fetal developmental sensitivity, genetic susceptibility, timing, and duration during pregnancy when alcohol is consumed, and other confounders such as polysubstance abuse or socioeconomic status. Although binge drinking may not be as concerning as chronic heavy alcohol consumption, adverse developmental effects in the fetus can still occur, especially depending on whether the drinking occurred during critical stages of organ formation.35 In addition, fetal alcohol metabolism is slower than in the mother so there may be higher levels of alcohol sustained longer in fetal blood than in maternal blood.15,16
Prenatal alcohol exposure has been associated with multiple fetal structural anomalies including renal, cardiac, craniofacial, and other major malformations. Several characteristic craniofacial abnormalities include short palpebral fissures, a smooth philtrum, and a thin vermillion border of the upper lip.36,37 A previous prospective cohort study from Australia examined the association between prenatal alcohol exposure and the craniofacial shape of children at 12 months of age.12 Researchers followed and obtained information regarding alcohol consumption in 451 women 3 months before pregnancy and then each trimester with a subsequent 3-dimensional craniofacial assessment of children at 12 months of age.12 The study found that low-dose levels of prenatal alcohol can influence fetal craniofacial development but the clinical significance of this finding remains unknown.12
Previous studies have noted that overall maternal alcohol consumption, including first-trimester or late-pregnancy use, can be associated with intrauterine growth restriction as well as an increased risk of stillbirth.14,38,39 However, the impact of maternal specifically low-dose alcohol consumption on birth outcomes is not well understood. Several previous systematic reviews found that it had little or no effect on intrauterine growth restriction, preterm labor, spontaneous abortion, or stillbirth.11,12
It is unclear whether a single binge drinking episode in early gestation, during increased teratogen susceptibility, results in an increased fetal risk or impacts future child development. A previous prospective observational study, conducted over a decade, examined 51 preschool-aged offspring of nonalcohol-dependent women who engaged in 1 to 5 binge drinking episodes during the first trimester and compared them with 51 children not exposed to any teratogens.40 Depending on the child’s age, abilities and behavior in preschool offspring were assessed using validated scales. The study noted behavioral differences of preschool-aged children within 3 of 9 scales, specifically a greater degree of disinhibited behavior but no differences in regards to physical, language, or cognitive outcomes.40
Although the association between chronic heavy alcohol consumption during pregnancy and adverse neurodevelopmental effects in childhood has been well studied, the effect of low-dose maternal drinking has been more difficult to elucidate. A previous large multinational systematic review from multiple countries, including the United States, England, and Australia, examined the cognitive, mental health, and socioemotional development of 3- to 16-year-old children following pregnancies with maternal low-dose alcohol consumption. The authors reported evidence of subtle long-term cognitive and behavioral effects such as inattention, mental health problems, and difficulties with short-term memory.41 A different study from Washington state followed children after low-moderate maternal alcohol consumption in pregnancy up to age 18 and found that half of the older children diagnosed with FAS exhibited normal developmental scores as preschoolers but by age 10 all had severe brain dysfunction (http://depts.washington.edu/fasdpn/).42 Only 10% of children diagnosed with FAS in this study had attention difficulties by age 5 but 60% were affected by age 10 and 100% had severe dysfunction in areas such as language, memory, and activity level (http://depts.washington.edu/fasdpn/).42
The FASD spectrum refers to a group of conditions that can occur in a person whose mother consumed alcohol during pregnancy and has lifelong implications (Fig. 1). Although the prevalence is difficult to assess, the CDC and other studies estimate 0.2 to 7 infants with FASD for every 1000 live births in certain areas of the United States.45,46 FAS is considered the most common teratogenically induced, nonhereditary form of mental deficiency throughout the western world. It is associated with reduced intelligence,47 attention disorders,48,49 neuropsychological deficits,50–53 physical abnormalities including facial dysmorphology,15,16 sleep disorders, and behavioral problems.
There is no cure for FASD and it is irreversible but it can be completely prevented if women abstain from alcohol consumption while pregnant or when trying to conceive given women often do not recognize they are pregnant until 4 to 6 weeks postconception.54,55
This represents the most involved end of the FASD spectrum. Those affected by FAS might have abnormal facial features, growth problems, central nervous system abnormalities, and difficulties with learning, memory, attention span, communication, vision, or hearing. Often, people with FAS have problems in school and trouble socially with others. The global prevalence of FAS in children and youth in the general population has been estimated to be 7.7 per 1000 population.56 A study aiming to identify the prevalence of FASD among first-grade students in a representative Midwestern US community estimated that FAS in that community likely ranged from 6 to 9 per 1000 children with the total rate of FASD likely ranging from 24 to 48 per 1000 children.57 This study also found that the most predictive maternal risk factors associated with the cognitive, behavioral, and neurodevelopmental effects seen in children with FASD are late recognition of pregnancy, the quantity of alcoholic drinks consumed 3 months before pregnancy and the quantity of drinking reported by the child’s father.
ALCOHOL-RELATED NEURODEVELOPMENTAL DISORDER
People with alcohol-related neurodevelopmental disorder can have intellectual disabilities and issues with behavior and learning. School is often challenging and they have difficulty with math, memory, attention, judgement, and poor impulse control.
ALCOHOL-RELATED BIRTH DEFECTS
Those with alcohol-related birth defect can have structural abnormalities of the heart, kidneys, and bones. They can also have complications with hearing.
Children With FASD
It is difficult to diagnose FASD because there is no biological test and other disorders such as attention-deficit/hyperactivity disorder and Williams syndrome have similar symptoms. Diagnosis includes evaluating for features of abnormal facial features, lower-than-average height and/or weight, central nervous system abnormalities (eg, small head circumference, problems with attention and hyperactivity, poor coordination) and prenatal alcohol exposure; although, confirmation of maternal alcohol consumptions is not required to diagnose FASD.
The prevalence of FASD in the United States has been noted to be as high as 1 to 5 per 100 school-aged children with FAS occurring in up to 6 to 9 of 1000 school-aged children.46,57–59 The cost to the United States for FAS alone, not including people with FASD, is over $4 billion annually with the lifetime cost of 1 individual with FAS of ∼$2 million in 2002.46,57–59
Although FASD is irreversible, research has shown that early intervention services, from birth to 3 years of age, can improve a child’s development.60–62 These interventions include medications to ameliorate symptoms, behavior and education therapy, parent training, and other alternative approaches.60–62
Studies have also shown that some protective factors can help mitigate the adverse effects of FASD including diagnosis of FASD before the age of 6, a loving, nurturing, and stable home environment during school-age years, the absence of violence, and involvement in special education and social services.60–62 When children are diagnosed at a young age, they can then be placed in appropriate educational classes to receive appropriate social services that are geared to their specific needs and learning style. As children with FASD can be more sensitive to disruptions in lifestyle or routine, a stable home life can help prevent secondary conditions, such as criminal behavior, unemployment, and incomplete education that they are at increased risk for.
There is no specific medication approved for the treatment of FASD but there are different types of medications that can alleviate FASD symptoms including stimulants, antidepressants, neuroleptics, and anxiolytics.
NEUROBEHAVIORAL DISORDER ASSOCIATED WITH PRENATAL ALCOHOL EXPOSURE (ND-PAE)
ND-PAE refers to children exposed prenatally to alcohol that do not satisfy the full criteria for a diagnosis of FAS. This is a recognized condition in the Diagnostic and Statistical Manual 5 of the American Psychiatric Association since 2013. To meet criteria, the mother of the child must have consumed greater than minimal levels of alcohol, >13 alcohol drinks per month or >2 alcohol drinks in 1 sitting, prenatally. Children diagnosed with ND-PAE have difficulties in 3 areas: (1) thinking and memory; (2) behavior problems; and (3) trouble with day-to-day living. Problems in these areas can include problems with forgetting material learned, severe tantrums, irritable mood, difficulty shifting attention between tasks, playing with other children, and activities of daily living like bathing.
Animal Studies of Prenatal Alcohol Exposure
Evidence from previous animal studies have found prenatal alcohol exposure to disrupt normal fetal developmental processes through a multitude of mechanisms including disruption of cellular metabolism (ie, oxidative stress, suppression of protein, and DNA synthesis), impairment of cell acquisition, altered gene expression, interference with growth factor signaling, increased cell damage and apoptosis, and altered placental function and hemodynamics resulting in fetal hypoxia.11,63–71
A previous nonhuman primate (NHP) study of Rhesus macaques focused on evaluating the effects of chronic early gestation alcohol exposure on placental function and fetal brain development.71 Animals were trained to orally self-administer ethanol solution daily throughout the first trimester and all underwent Doppler-ultrasound followed by placental and fetal magnetic resonance imaging (MRI). This study concluded that chronic first-trimester ethanol exposure significantly reduced placental perfusion and oxygen supply to the fetal vasculature later in pregnancy.71 These perturbations of placental function were associated with impaired fetal weight and brain development. Specifically, ethanol-exposed NHP fetuses showed significantly smaller fetal biparietal diameter and brain weight, consistent with previous MRI studies in murine72 and rat models73,74 showing structural brain abnormalities from first-trimester ethanol exposure and microcephaly that is routinely observed with FAS in human neonates.75 In addition, T2-weighted MRI images of the NHP fetal brain to measure brain volume and surface area was indicative of impaired growth and development.71
In addition, another NHP study simulated a once-per-week human binge drinking pattern and showed an increase in fetal facial anomalies, growth deficiency, and central nervous system dysfunction.76 Even in animals without structural anomalies, behavioral abnormalities were observed.77 A different NHP study followed offspring for the first 24 months of life who had been exposed in utero to once weekly maternal ethanol consumption continued through the first versus second versus third trimester.77 This study found that fetuses exposed to alcohol earlier in gestation were associated with more severe and debilitating cognitive abnormalities than those with later exposure in pregnancy.77 Other animal studies evaluating the effects of a single binge drinking incident prenatally have shown fetal neurotoxic effects.78–80
Recognization and Screening
Previous studies have shown that even low levels of prenatal alcohol exposure can negatively affect the developing fetus81–84 and the earlier in pregnancy women can stop drinking, the better the outcome85; thus, there is increasing importance to identify women who drink during pregnancy. Screening all women of childbearing age and those who are pregnant regarding their alcohol consumption is a practical process to identify women at risk for maternal drinking for earlier recognition of potentially exposed fetuses and to diagnose FASD sooner. This can result in a reduction of primary FASD disabilities as well as secondary disabilities often related to FASD in the absence of diagnosis.
Structured questionnaires can also be used to screen pregnant women for alcohol use but this can be challenging because traditional alcohol-screening questionnaires such as the Michigan Alcoholism Screening Test (MAST)86 and the CAGE screening instrument87 are less effective in identifying drinking problems among women compared with men. This is secondary to the biological differences between women and men as well as different patterns of alcohol consumption and thresholds for problem drinking. As such, there are newer brief alcohol-screening questionnaires designed specifically for the prenatal setting and of those, T-ACE has the highest at-risk drinking sensitivity (69% to 88%).88,89 However, a limitation of screening questionnaires is that there is underreporting bias of maternal alcohol consumption due to inaccurate patient recall, embarrassment, or denial regarding actual consumption.90–93
At this time, there is no laboratory test that can definitively detect and quantify prenatal alcohol use.94 Current laboratory testing is limited by the short half-life of alcohol in the blood stream making it difficult to detect; negative results do not rule out alcohol use and a positive test fails to reveal a pattern of alcohol use. Traditionally, maternal and neonatal urine and blood samples have been used to determine prenatal alcohol use.95,96 However, the biomarkers measured from these samples mostly reflect alcohol exposure within 2 to 3 days before delivery. Other samples such as amniotic fluid, umbilical cord blood, neonatal hair, placenta, breast milk, vernix, or meconium have also been considered. Meconium, often used to detect prenatal exposure to drugs, has been studied to measure fatty acid ethyl esters (FAEE) as a biomarker for prenatal alcohol use that may reflect exposure since the 13th week of pregnancy when meconium first begins to form.94,97–99 However, the correlation between FAEE in meconium and prenatal alcohol use is not perfect94,98 as it may accumulate unevenly in meconium over time and there are genetic variations in alcohol metabolism that may influence the synthesis of FAEE, and illness, medications, or food additives can affect FAEE concentrations. A previous study examining the benefits of universal meconium screening for maternal drinking during pregnancy found that such screening is premature and would only be effective if a societal willingness to institute prevention and intervention programs to improve women and children’s health was in place.100
Interventions for Women to Stop Drinking
Maternal substance use remains highly stigmatized, thus making pregnant women more reluctant to disclose problems associated with their substance use when attempting to use services.101 Brief interventions are a collection of time-limited counseling strategies geared toward facilitating the reduction or elimination of at-risk alcohol use in patients. Three components to a more successful brief intervention are: (1) assessment and feedback after assessment; (2) advice and discussion of strategies for reducing or eliminating problematic alcohol use; and (3) assistance in the form of eliciting ideas about change strategies, goal setting, positive reinforcement, and referrals to supportive services.102 Strong evidence exists to that brief behavioral counseling interventions occurring preconception, prenatally, or postpartum can reduce the incidence of alcohol-exposed pregnancy in women who engage in at-risk drinking.15,16,103 A previous study reported that pregnant women in the brief intervention group were 5 times more likely than women in the control group to have reported that they abstained from alcohol.103 The most common form of brief intervention in pregnant women is motivational interviewing, which motivates individuals to change behaviors through exploring and resolving discrepancy and ambivalence. It has been specifically effective in helping women who are drinking problematically prevent an alcohol-exposed pregnancy.
Harm reduction is another approach that has been found to be helpful in assisting women to reduce harms associated with substance use and with establishing realistic and attainable goals to decrease their alcohol consumption while working toward abstinence. This method strives to shift away from stigma, guilt, confrontation, and shame but instead works toward empowerment.
Pregnant women who are alcohol dependent are more likely to have difficulties quitting than those without dependency problems and thus need specialized counseling and more intense support. They are also more likely to have a wide range of other health problems that may need attention as most often alcohol problems and dependency are symptomatic of underlying social and emotional difficulties.15,16,104 In this setting, home-visiting advocacy has been shown to be helpful.105,106
As comprehensive prenatal care can mitigate some of the maternal, fetal, and neonatal complications secondary to maternal alcohol abuse, it is recommended that health care providers should screen all pregnant women for alcohol use, counsel pregnant women regarding the risks of alcohol consumption, assemble a multidisciplinary team of medical and social service providers to comprehensively assess women with alcohol abuse and their offspring, schedule frequent prenatal visits for antenatal surveillance of maternal and fetal status, provide pregnant women with education and support, and obtain an early dating ultrasound to more accurately follow fetal growth throughout gestation.107
Alcohol Use While Breastfeeding
Many studies have documented the harmful effects of alcohol consumption during pregnancy; however, there are limited data on the impact of maternal alcohol consumption while breastfeeding. It has been reported that the concentration of alcohol in breast milk is similar to that of maternal blood concentration.108 Alcohol has the ability to freely pass through a lactating mother’s milk and thus lactating mothers who decide to continue to drink should avoid breastfeeding 3 to 4 hours after moderate to high consumption of alcohol.108 At moderated doses of alcohol consumption (1 to 2 drinks), there are negligible amounts of alcohol present within a lactating mother’s milk thus making it less harmful for a mother to breastfeed their infant.109
This is of concern because among women who consume alcohol during the pregnancy, the majority continues to drink throughout their lactation period. It has been reported that 35% to 80% of mothers consume alcohol during lactation,110 but of concern a study showed that only 13% of lactating mothers reported receiving advice from their primary health care provider about the detrimental effects of drinking while breastfeeding.111 This collectively suggests a lack of uniform communication between health care providers and their patients about the risks of alcohol consumption throughout lactation.
Alcohol consumption can also significantly impact the neuroendocrine state of a mother and as a result, a decreased ability to breastfeed. Two major hormones play a vital role in breastfeeding: oxytocin, which is essential for contraction of mammary glands, and prolactin, which stimulates the production of breast milk.112 A number of studies have found that alcohol consumption while lactating decreases both these hormones. One specific study showed a >75% decrease in oxytocin levels after alcohol consumption.112 Previous studies have also shown that a nursing infant consumes significantly less milk after maternal alcohol consumption, mostly because of a lack of milk production rather than palatability.113
Although there are limited data regarding the impact of maternal alcohol consumption on breastfeeding infants, it is associated with increased adverse effects on the offspring. A previous study examining the effect of alcohol consumption during lactation in 400 infants reported a significant reduction in psychomotor index in infants exposed to alcohol during lactation. They also established a dose-response and reduction in psychomotor index. Furthermore, it has been previously reported that consumption of alcohol can impose intellectual deficiencies such as attention-deficit hyperactivity disorder114 and affect infant sleep patterns. In a small clinical study, mothers of 23 infants consumed moderate amounts of alcohol 3 hours before nursing and the sleep patterns of the infants were monitored for the next 24 hours.112 This study revealed that the infants’ sleep patterns were affected when alcohol was consumed by their mothers 3 hours before the infant falling asleep.
FAS disorder spectrum and other adverse fetal effects secondary to maternal alcohol consumption prenatal alcohol exposure will continue to be a substantial public health concern and afflict future generations without successful prevention, intervention, and management. The times before, during and after pregnancy are all critical periods for maternal alcohol consumption awareness, reduction, and ideally abstinence. An increased awareness among the general public and health care providers combined with effective universal prevention strategies and improved guidelines for the detection, prevention, and management of FASD, are important measures in addressing this ongoing concern. Although preconception alcohol cessation is preferred, this recommendation is unavailable to at least 30% to 50% of women whom pregnancies are unplanned.10 Pregnancy is a unique time when women are motivated to adopt healthy behaviors that may potentially benefit their child. Knowing that fetal alcohol exposure is the most common nongenetic cause of cognitive impairment, it is critical to identify maternal alcohol consumption early as a primary target to prevent downstream FASD. Therefore, innovative research studies are vital to better understand the mechanism of alcohol on pregnancy to then target the development of therapeutic strategies to mitigate its adverse effects and improve maternal and fetal outcomes.
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