New and Novel Treatments for Gynecologic CancerPreventing Ovarian Cancer in High-risk Women: One Surgery at a TimeSWANSON, CASEY L. PA-C; BAKKUM-GAMEZ, JAMIE N. MDAuthor Information Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Surgery, Mayo Clinic, Rochester, Minnesota The authors declare that they have nothing to disclose. Correspondence: Jamie N. Bakkum-Gamez, MD, Eisenberg Lobby 71, Mayo Clinic, Rochester, MN. E-mail: [email protected] Clinical Obstetrics and Gynecology: March 2020 - Volume 63 - Issue 1 - p 64-73 doi: 10.1097/GRF.0000000000000499 Buy Metrics Abstract Eleven genes have been identified that increase the lifetime risk of developing ovarian cancer. The cumulative cancer risk of ovarian cancer varies with the mutation type and age. Ovarian cancer risk management options include surgical risk reduction with salpingo-oophorectomy and a newer step-wise approach with interval salpingectomy and delayed oophorectomy. Women should be counseled on the pros and cons of hysterectomy in the setting of reducing the risk of other cancers; eliminating the risk of endometrial cancer in Lynch Syndrome, potential risk of serous/serous-like endometrial cancer in BRCA1 carriers, and elimination of progestogen therapy that may increase breast cancer risk. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.