Opioid Use, Misuse and Abuse: The Rise and Fall of a National Opioid EpidemicPsychology of Chronic Pelvic Pain Prevalence, Neurobiological Vulnerabilities, and TreatmentTILL, SARA R. MD, MPH*; AS-SANIE, SAWSAN MD, MPH*; SCHREPF, ANDREW PhD†Author Information Departments of *Obstetrics and Gynecology †Anesthesiology, University of Michigan, Ann Arbor, Michigan S.A.-S. is supported by NIH R01 R01 HD088712 and is a consultant for Abbvie and Myovant. The remaining authors declare that they have nothing to disclose. Correspondence: Sara R. Till, MD, MPH, Department of Obstetrics and Gynecology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI. E-mail: firstname.lastname@example.org Clinical Obstetrics and Gynecology: March 2019 - Volume 62 - Issue 1 - p 22-36 doi: 10.1097/GRF.0000000000000412 Buy Metrics Abstract Patients with pelvic pain suffer from psychological conditions at a disproportionately high rate compared with their peers. We review environmental, genetic, inflammatory, and neurobiological factors that increase vulnerability to developing both of these conditions. We review treatment strategies for chronic pelvic pain in patients who have comorbid psychological conditions, including both nonpharmacologic and pharmacologic options. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.