Depression in the Pregnant PatientPredictors of Postpartum Depression: A Comprehensive Review of the Last Decade of EvidenceGUINTIVANO, JERRY PhD*; MANUCK, TRACY MD†; MELTZER-BRODY, SAMANTHA MD, MPH*Author Information Departments of *Psychiatry †Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Supported by the National Institutes of Mental Health: JG grant 4T32MH093315-05 and SMB grant R01MH104468. S.M.-B. receives grant support funding to UNC from Sage Therapeutics and Janssen. The remaining authors declare that they have nothing to disclose. Correspondence: Samantha Meltzer-Brody, MD, MPH, Department of Psychiatry, Chapel Hill, NC. E-mail: [email protected] Clinical Obstetrics and Gynecology: September 2018 - Volume 61 - Issue 3 - p 591-603 doi: 10.1097/GRF.0000000000000368 Buy Metrics Abstract Postpartum depression (PPD) is one of the most frequent complications of childbirth affecting ~500,000 women annually (prevalence 10% to 15%). Despite the documented adverse outcomes for mother and child, there remains a great need to develop prospective approaches to identify women at risk. This review examines some of the best-characterized molecular and clinical risk factors for PPD. We illustrate that this is a growing literature but there remains a lack of reliable molecular predictors for PPD. Current best predictors are clinical assessments for psychiatric history and adverse life events, highlighting the need for increased depression screening across the perinatal period. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.