The Prevention and Management of Thrombosis in Obstetrics and GynecologyDiagnosis and Management of VTE in PregnancyMcLEAN, KELLEY C. MD*; JAMES, ANDRA H. MD, MPH†Author Information *Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont Larner College of Medicine, Burlington, Vermont †Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina The authors declare that they have nothing to disclose. Correspondence: Kelley C. McLean, MD, University of Vermont Larner College of Medicine, 111 Colchester Avenue, Burlington, VT. E-mail: [email protected] Clinical Obstetrics and Gynecology: June 2018 - Volume 61 - Issue 2 - p 206-218 doi: 10.1097/GRF.0000000000000354 Buy Metrics Abstract Venous thromboembolism is a leading cause of maternal death. Because of the low absolute frequency of events, however, outcome-based clinical data are limited. Consequently, clinicians must additionally rely both on published guidelines and on extrapolation of data from studies focused on nonpregnant individuals. The diagnosis and treatment of deep vein thrombosis, pulmonary embolism, and cerebral vein and dural sinus thrombosis are complicated by pregnancy, and often require modifications to standard diagnostic and treatment algorithms outside of pregnancy. Treatment of VTE in pregnant women is in particular need of future research. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.