Perinatal Viral Infections: Considering Achievements, Opportunities, and Paradoxes in ManagementHerpesviridae Infection: Prevention, Screening, and ManagementSUBRAMANIAM, AKILA MD, MPH*; BRITT, WILLIAM J. MD† Author Information *Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Center for Women’s Reproductive Health, Birmingham, Alabama †Pediatric Division of Infectious Diseases, the University of Alabama at Birmingham, Birmingham, Alabama The authors declare that they have nothing to disclose. Correspondence: Akila Subramaniam, MD, MPH, Women and Infants Center, Suite 10270, Birmingham, AL. E-mail: [email protected] Clinical Obstetrics and Gynecology: March 2018 - Volume 61 - Issue 1 - p 157-176 doi: 10.1097/GRF.0000000000000335 Buy Metrics Abstract Bacterial, viral, and parasitic pathogens add significant morbidity and even mortality to pregnancy—with adverse effects extending to both the gravida and the newborn. Three herpesviruses deserve considerable attention given the effects of perinatal infection on obstetric outcomes, specifically maternal and neonatal morbidity. In the following review, we will provide a description of cytomegalovirus, herpes simplex virus, and varicella zoster virus. For each viral pathogen, we will describe the epidemiology, natural history, screening and diagnosis modalities, treatments, and implications for antepartum care. Furthermore, we will highlight future directions of work in reducing the morbidities associated with these viral pathogens. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.